MAP3K12 and TSC22D1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAP3K12	TSC22D1
Description		mitogen-activated protein kinase kinase kinase 12	TSC22 domain family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation JNK Cascade Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Positive Regulation Of ERK1 And ERK2 Cascade	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 28892062) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)
Interacting Genes		16 interacting genes: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP MTDH RGS1 RPL18A SH3RF1 TGM2 TSC22D1	56 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC88C CCDC90B CHD3 CKAP2 CORO2B CRMP1 DDAH2 DNASE1 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 GTF2F2 HMGXB4 KMT2B KMT2C LPAR6 LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RFXAP RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1
Entrez ID		7786	8848
HPRD ID		02709	07414
Ensembl ID		ENSG00000139625	ENSG00000102804
Uniprot IDs		A0A024RAY5 Q12852	A0A024RDV8 A0A087X0H8 A8K3Y6 Q15714
PDB IDs		5CEN 5CEO 5CEP 5CEQ 5VO1 5VO2
Enriched GO Terms of Interacting Partners?
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