ZNF177 and ARHGAP21

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ZNF177	ARHGAP21
Description		zinc finger protein 177	Rho GTPase activating protein 21
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Blood Microparticle	Golgi Membrane Golgi Apparatus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Cytoplasmic Vesicle Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	GTPase Activator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Golgi Organization Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Golgi Localization Establishment Of Golgi Localization Maintenance Of Golgi Location Organelle Transport Along Microtubule
Pathways			RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Birth weight ( 31043758) Diisocyanate-induced asthma ( 25918132) Immature fraction of reticulocytes ( 32888494) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Optic disc area ( 31798171) Optic disc size ( 31809533) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		22 interacting genes: ARHGAP21 BOLA2 BOLA2B CIB3 CSNK2A1 CT55 EXOC8 KEAP1 LMO1 MID2 MLH1 PMVK PRKAB2 PRKAR1B PSMB1 RHOU SLC37A3 SNAP25 SNAPC5 TRAF4 TYK2 ZGPAT	8 interacting genes: ARF1 EEF1D ODAD2 PTK2B RHOA SP1 TULP3 ZNF177
Entrez ID		7730	57584
HPRD ID		03175	06445
Ensembl ID		ENSG00000188629	ENSG00000107863
Uniprot IDs		Q13360	Q5T5U3
PDB IDs			2DHJ 2J59 2YUY
Enriched GO Terms of Interacting Partners?
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