ARHGAP21 and ZNF177

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ARHGAP21	ZNF177
Description		Rho GTPase activating protein 21	zinc finger protein 177
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Cytoplasmic Vesicle Membrane	Nucleus Blood Microparticle
	Molecular Function	GTPase Activator Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Golgi Organization Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Golgi Localization Establishment Of Golgi Localization Maintenance Of Golgi Location Organelle Transport Along Microtubule	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Birth weight ( 31043758) Diisocyanate-induced asthma ( 25918132) Immature fraction of reticulocytes ( 32888494) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Optic disc area ( 31798171) Optic disc size ( 31809533) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		8 interacting genes: ARF1 EEF1D ODAD2 PTK2B RHOA SP1 TULP3 ZNF177	22 interacting genes: ARHGAP21 BOLA2 BOLA2B CIB3 CSNK2A1 CT55 EXOC8 KEAP1 LMO1 MID2 MLH1 PMVK PRKAB2 PRKAR1B PSMB1 RHOU SLC37A3 SNAP25 SNAPC5 TRAF4 TYK2 ZGPAT
Entrez ID		57584	7730
HPRD ID		06445	03175
Ensembl ID		ENSG00000107863	ENSG00000188629
Uniprot IDs		Q5T5U3	Q13360
PDB IDs		2DHJ 2J59 2YUY
Enriched GO Terms of Interacting Partners?
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