TRIM26 and DDX41

Number of citations of the paper that reports this interaction (PubMedID 33373584)
7

Data Source:
BioGRID (pull down)

		TRIM26	DDX41
Description		tripartite motif containing 26	DEAD-box helicase 41
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus Cytoplasm Cytosol	Nucleus Spliceosomal Complex Cytosol Membrane Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell	MRNA Splicing, Via Spliceosome Apoptotic Process Cell Population Proliferation Cell Differentiation
Pathways		Interferon gamma signaling	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) General cognitive ability ( 29844566) Hematocrit ( 32888494) LDL cholesterol levels ( 32203549) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 21926974 22883433 30285260) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: BEND7 BIVM DDX41 EPN2 EPN3 INCA1 IRF3 LMNA MACROH2A1 MAGEA6 MIR138-2 MIR18B MNAT1 OTUB2 PHF7 RABEP1 RNF10 RNF126 SUMO2 THAP1 TLE5 TRIM41 UBE2D1 UBE2D2 UBE2D3 USP36 USP39 USP5	10 interacting genes: AIDA CEP70 CHAF1A KLC2 NKAPL OGT SIAH1 TRIM26 TRIM41 TUBG1
Entrez ID		7726	51428
HPRD ID		02901	10490
Ensembl ID		ENSG00000234127	ENSG00000183258
Uniprot IDs		A0A024RCP3 Q12899	B3KRK2 Q9UJV9
PDB IDs			2P6N 5GVR 5GVS 5H1Y
Enriched GO Terms of Interacting Partners?
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