SF1 and TRIM69

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		SF1	TRIM69
Description		splicing factor 1	tripartite motif containing 69
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome Nuclear Body	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Pre-mRNA Branch Point Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Male Sex Determination Nuclear Body Organization Leydig Cell Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Steroid Biosynthetic Process	Apoptotic Process Protein Ubiquitination
Pathways		mRNA Splicing - Major Pathway	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Artenimol
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Urate levels ( 21768215)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		60 interacting genes: APBB1 ATXN1 BCAS2 BCL2 CDC42 CIAO1 DDX17 DUX4L9 EWSR1 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IL7R ILF3 ITCH KRTAP26-1 MIR106B MIR155 MIR19B2 MIR34A MIRLET7G MKRN3 NCK2 NFKB1 OGT OSTF1 PLSCR1 PRKG1 PRPF40A PSMA3 PUF60 RBM10 RBM17 RBM4 RBM7 RBPMS SEC23A SF3A1 SF3B1 SF3B4 TAF15 TCERG1 TNPO2 TRIM23 TRIM69 TTN TXNL4B U2AF2 UBL5 VEGFB WBP4 WDR77 WDR83 WWP2 ZNF461	53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483
Entrez ID		7536	140691
HPRD ID		03306	11518
Ensembl ID		ENSG00000168066	ENSG00000185880
Uniprot IDs		A0A024R566 A0A024R572 A0A024R588 A0A024R5D9 B4DX42 Q15637	H0YL66 Q86WT6
PDB IDs		1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX	4NQJ 6YXE
Enriched GO Terms of Interacting Partners?
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