XPNPEP1 and HBG2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		XPNPEP1	HBG2
Description		X-prolyl aminopeptidase 1	hemoglobin subunit gamma 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle
	Molecular Function	Aminopeptidase Activity Manganese Ion Binding Protein Homodimerization Activity Metalloaminopeptidase Activity	Peroxidase Activity Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Haptoglobin Binding Hemoglobin Alpha Binding Organic Acid Binding Metal Ion Binding
	Biological Process	Proteolysis Bradykinin Catabolic Process	Oxygen Transport Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Biliary atresia ( 20460270) Bipolar disorder ( 31043756 28072414) Refractive error ( 32231278)	Beta thalassemia/hemoglobin E disease ( 20183929) Hemoglobin ( 28548082) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Malate levels ( 31560688) Mean corpuscular hemoglobin concentration ( 32888494 28453575) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		13 interacting genes: ANK3 DISC1 GORASP2 GSK3B HBG2 MAPK9 NUDT3 POLA2 RHOH RINT1 SUMO2 UBC UBE2D3	10 interacting genes: APP CYB5R3 HBA1 HBA2 HBB HBM HBQ1 RPSA SMAD5 XPNPEP1
Entrez ID		7511	3048
HPRD ID		03899	00792
Ensembl ID		ENSG00000108039	ENSG00000196565
Uniprot IDs		Q5T6H7 Q9NQW7	D9YZU9 P69892
PDB IDs		3CTZ	1FDH 4MQJ 4MQK
Enriched GO Terms of Interacting Partners?
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