EIF4H and CCL24

		EIF4H	CCL24
Description		eukaryotic translation initiation factor 4H	C-C motif chemokine ligand 24
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Extracellular Space
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding Cadherin Binding	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Sexual Reproduction Developmental Growth Eukaryotic Translation Initiation Factor 4F Complex Assembly	Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Inflammatory Response Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Eosinophil Migration
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			CCL24 levels ( 25147954) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sarcoidosis ( 32826979) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		12 interacting genes: C11orf68 CCL24 DDIT4L DLG3 FBXO17 LAT2 LNX1 PICK1 PTPN12 RFC2 SPG21 STT3B	8 interacting genes: CCL13 CCL21 CCL5 CCR3 CXCL11 EIF4E2 EIF4H XCL1
Entrez ID		7458	6369
HPRD ID		11940	03931
Ensembl ID		ENSG00000106682	ENSG00000106178
Uniprot IDs		Q15056	O00175
PDB IDs			1EIG 1EIH
Enriched GO Terms of Interacting Partners?
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