EIF4H and FBXO17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EIF4H	FBXO17
Description		eukaryotic translation initiation factor 4H	F-box protein 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding Cadherin Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Sexual Reproduction Developmental Growth Eukaryotic Translation Initiation Factor 4F Complex Assembly	Glycoprotein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			SAPHO syndrome ( 33816493)
Interacting Genes		12 interacting genes: C11orf68 CCL24 DDIT4L DLG3 FBXO17 LAT2 LNX1 PICK1 PTPN12 RFC2 SPG21 STT3B	22 interacting genes: ADAMTSL4 ADRB2 CBY2 CDCA8 DZIP3 EIF4H JRK KPRP KRT75 KRTAP13-2 LASP1 OAS2 PTPN21 RAB11FIP2 RUNX1 SAXO1 SAXO2 SKP1 USP54 ZNF213 ZNF829 ZSCAN9
Entrez ID		7458	115290
HPRD ID		11940	16436
Ensembl ID		ENSG00000106682	ENSG00000269190
Uniprot IDs		Q15056	Q96EF6
PDB IDs
Enriched GO Terms of Interacting Partners?
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