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SUMO1 and HGS
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
484
Data Source:
BioGRID
(two hybrid)
SUMO1
HGS
Description
small ubiquitin like modifier 1
hepatocyte growth factor-regulated tyrosine kinase substrate
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Nuclear Body
PML Body
Nuclear Speck
Nuclear Membrane
Nuclear Stress Granule
Lysosome
Endosome
Early Endosome
Cytosol
Early Endosome Membrane
Multivesicular Body Membrane
ESCRT-0 Complex
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Phagocytic Vesicle Lumen
Molecular Function
RNA Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Enzyme Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Small Protein Activating Enzyme Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin-specific Protease Binding
Protein Binding
Protein Domain Specific Binding
Phosphatidylinositol Binding
Ubiquitin Binding
Ubiquitin-like Protein Ligase Binding
Metal Ion Binding
Biological Process
DNA Repair
Negative Regulation Of Transcription By Transcription Factor Localization
Protein Sumoylation
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Action Potential
Negative Regulation Of Transcription, DNA-templated
Protein Stabilization
Roof Of Mouth Development
Cellular Response To Cadmium Ion
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Protein Targeting To Lysosome
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Membrane Invagination
Positive Regulation Of Gene Expression
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Endosomal Transport
Macroautophagy
Negative Regulation Of Angiogenesis
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Multivesicular Body Assembly
Regulation Of Protein Catabolic Process
Regulation Of MAP Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Localization To Membrane
Positive Regulation Of Exosomal Secretion
Pathways
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
EGFR downregulation
Lysosome Vesicle Biogenesis
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
RHOU GTPase cycle
Endosomal Sorting Complex Required For Transport (ESCRT)
Inhibition of membrane repair
Prevention of phagosomal-lysosomal fusion
RHOBTB3 ATPase cycle
Drugs
Citric acid
Diseases
GWAS
Eye color traits (
20463881
)
Refractive error (
32231278
)
Interacting Genes
152 interacting genes:
AR
ATF2
ATXN1
ATXN3
ATXN7
AXIN1
BIRC3
BLM
BRCA1
BTBD3
C11orf65
C18orf25
CANX
CARD9
CASP2
CASP8
CCR2
CDK6
CHAF1A
CHD3
CREBBP
DAXX
DEUP1
DNM1
DNMT3B
DTX2
EDARADD
EGLN3
EIF2AK2
ERCC6
ETV6
FAF1
FAM118B
FAS
FASLG
FBF1
FOS
FOXM1
GMCL1
HDAC4
HDAC9
HGS
HIF1A
HIPK2
HIPK3
HNRNPC
HNRNPK
HSF1
HTT
IKZF3
IRAK1
JUN
MAPK1IP1L
MDM2
MEF2A
MITF
MRE11
MRTFA
MSX1
MTOR
MUL1
MYB
NCOA1
NCOA2
NCOA3
NCOR2
NFE2L2
NFKBIA
NIN
NR3C1
NR3C2
PARK7
PAX6
PCNA
PDGFC
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PLAGL1
PML
PPM1J
PRKN
PROP1
PSIP1
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RHOXF2
RNF111
RNF167
RNF4
RPS3
SAE1
SALL1
SATB1
SENP1
SENP2
SENP6
SETX
SLC2A1
SOX10
SOX2
SOX6
SP100
SP3
SPOP
SREBF1
SREBF2
SUMO1P1
TDG
TDP2
TFCP2
TMIE
TNFRSF1A
TOE1
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP73
TRAF2
TRAF4
TRAF5
TRIM24
TRPS1
TSC22D3
UBA2
UBE2I
USP25
USPL1
WRN
XPO1
ZBED1
ZBTB16
ZBTB2
ZBTB26
ZBTB6
ZCCHC12
ZCCHC7
ZFP42
ZHX1
ZMYM2
ZMYM3
ZMYM5
ZNF451
328 interacting genes:
ABI2
ACLY
ACOT11
ACTN3
ADRA2C
AHCYL1
AKAP8L
ANKRD55
ANTKMT
APC
APLP2
APP
ARFIP2
ARL6IP1
ARMC7
ASB12
ATN1
ATP1A1
ATP2A2
ATXN1L
BBC3
BCAS2
BEGAIN
BFSP2
BICRAL
BLOC1S1
BORCS6
BRINP3
BSG
C11orf1
C1orf94
C20orf173
C3orf36
C9orf24
CASK
CBS
CCDC103
CCDC136
CCDC196
CCDC33
CCND3
CDR2
CDSN
CEACAM6
CEP55
CEP57L1
CEP63
CEP68
CLTC
COG8
CRMP1
CRX
CSNK2A1
CSTF2
CSTF2T
CTTNBP2NL
CYB5R2
DAAM2
DAZAP2
DCTN2
DECR1
DEUP1
DGCR6
DLG4
DSN1
DTX2
DYDC1
EFHC2
EGFL7
EGFR
EHMT2
EIF3F
EPS15
ESRRG
EXOC3L1
EXOC5
EXOC7
EXOC8
EYA2
FAM166A
FAM168A
FAM185A
FANCG
FBN1
FCHSD2
FIGN
FLOT1
FLOT2
FNDC11
FOXD4L1
FOXI1
FSD2
FTCD
GATC
GFAP
GFI1B
GGA2
GKAP1
GOLGA2
GOLGA6L9
GOLGA7B
GUCA1C
HAP1
HAUS1
HNRNPDL
HNRNPM
HSF4
HSFY1
HSPA8
ICA1L
IFNA16
IFT74
IL2RB
IL4R
ILKAP
ING5
INTS4
IPO4
JAKMIP2
JMJD7
KIAA0753
KIAA0825
KLF4
KRT13
KRT14
KRT15
KRT16
KRT18
KRT19
KRT24
KRT25
KRT26
KRT27
KRT3
KRT31
KRT33B
KRT34
KRT35
KRT36
KRT37
KRT38
KRT39
KRT40
KRT6A
KRT75
KRT76
KRT82
KRT86
KRTAP19-5
KRTAP26-1
KRTAP7-1
LASP1
LDOC1
LINC00265
LITAF
LMO1
LMO4
LRRC61
LURAP1
LYST
MAGEB4
MAGED1
MAP3K1
MAP3K10
MAP3K7
MAPK1IP1L
MARK4
MAT2A
MED21
MED22
MED25
MED30
MED4
MED7
MEIS3
MEST
MET
METTL27
MIF4GD
MKNK1
MKRN3
MRFAP1L1
MTHFD1L
NADSYN1
NDC80
NDUFB10
NEDD4
NEDD8
NEFL
NF2
NFYC
NMI
NPAS2
NUP54
NUP62
NUTM2F
ODAD1
ODAM
OIP5
OSBPL5
P4HA3
PAK1
PAX5
PAX6
PEF1
PELP1
PFKM
PIK3R1
PITX1
PKNOX2
PLA2G10
PLAAT1
PLCD1
PLD3
PLEKHB2
PMEPA1
PNMA1
POGZ
POU2AF1
POU6F2
PPP1R16A
PPP1R32
PPP1R7
PPP2R3B
PRR22
PRR5
PSMB11
PSMB4
PTCD3
RASSF4
RBCK1
RFC2
RFX6
RHOBTB3
RINT1
RNF4
RPRD1A
RPS3A
RSPO4
RSU1
RUNX1
SAPCD1
SCAMP3
SCRN1
SCT
SDS
SERGEF
SERTAD3
SF3B3
SHANK3
SMAD2
SMAD3
SMAD5
SMARCB1
SNAP25
SNX1
SNX5
SNX7
SORBS3
SPATA12
SPC25
SPIRE2
SS18L1
STAM
STAM2
STK32C
STMN3
STX11
STXBP1
SUMO1
SUN2
SYK
TADA2A
TASOR2
TBX19
TCP11L2
TEKT1
TEKT5
TFG
TIMM10B
TIMMDC1
TJP2
TLE5
TMCC2
TOM1L1
TP53BP1
TRAF1
TRAF4
TRAK1
TRAP1
TRIM10
TRIM17
TRIM23
TRIM27
TRIM54
TRIM69
TRIM73
TRIML2
TSC1
TSG101
TUBB
TUBB2A
UBA1
UBA52
UBAP2
UBB
UBC
UBE2I
UBE4B
UBQLN1
UBQLN4
UBQLNL
UBXN11
USHBP1
USP54
VGLL3
VMP1
VPS37A
VPS37B
VPS37C
VPS37D
VPS52
WASHC1
YPEL3
ZNF302
ZNF34
ZNF430
ZNF44
Entrez ID
7341
9146
HPRD ID
03554
05085
Ensembl ID
ENSG00000116030
ENSG00000185359
Uniprot IDs
A0A024R3Z2
P63165
A0A0S2Z4R4
O14964
PDB IDs
1A5R
1TGZ
1WYW
1Y8R
1Z5S
2ASQ
2BF8
2G4D
2IO2
2IY0
2IY1
2KQS
2LAS
2MW5
2N1A
2N1V
2PE6
2UYZ
2VRR
3KYC
3KYD
3RZW
3UIP
4WJN
4WJO
4WJP
4WJQ
5AEK
5B7A
5ELJ
5GHD
6EOP
6EOT
6J4I
6JXU
6JXV
6K5T
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
6UYX
6UYY
6UYZ
6V7P
6V7Q
6V7R
6V7S
6WW3
2D3G
3F1I
3OBQ
3ZYQ
4AVX
Enriched GO Terms of Interacting Partners
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