U2AF1 and PRPF19

Number of citations of the paper that reports this interaction (PubMedID 22365833)
163

Data Source:
BioGRID (two hybrid)

		U2AF1	PRPF19
Description		U2 small nuclear RNA auxiliary factor 1	pre-mRNA processing factor 19
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GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome U2AF Complex	Prp19 Complex Nucleus Nucleoplasm Cytoplasm Lipid Droplet Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	DNA Damage Checkpoint Signaling Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Nonhomologous End Joining Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Cellular Protein Localization Positive Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Blood and toenail selenium levels ( 25343990)
Interacting Genes		53 interacting genes: AP1B1 AP2B1 CARNMT1 CHERP CIR1 CLK2 DHX38 EFHC2 EPB41 FRA10AC1 HINFP HMGB2 HNRNPK HNRNPM IL7R JMJD6 KRT1 KRT75 MAP1B MEOX2 MFAP1 MLH1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A PTEN RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRNP35 SNRPD1 SRPK1 SRRM4 SRSF1 SRSF2 SRSF3 SUV39H1 TOE1 TRA2B TRAPPC10 U2AF2 VEGFA ZCCHC10 ZNF417 ZRANB2 ZRSR2	16 interacting genes: DDX42 DNTT EGLN3 ESR1 EXOC7 GSTK1 HSPB1 OGT POLR2A PRPF8 PSMB4 PTEN RPA3 U2AF1 UBE2D3 VPS35
Entrez ID		7307	27339
HPRD ID		01871	12214
Ensembl ID		ENSG00000160201	ENSG00000110107
Uniprot IDs		P0DN76 Q01081 Q7Z780	Q9UMS4
PDB IDs		1JMT	4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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