C5 and VEZT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		C5	VEZT
Description		complement C5	vezatin, adherens junctions transmembrane protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Exosome	Acrosomal Vesicle Stereocilia Ankle Link Complex Nucleoplasm Cytosol Plasma Membrane Adherens Junction Integral Component Of Membrane Stereocilium Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity	Myosin Binding
	Biological Process	In Utero Embryonic Development Chemotaxis Inflammatory Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Positive Regulation Of Chemokine Production Positive Regulation Of Angiogenesis Cell Chemotaxis	Cell-cell Adhesion
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24390342 20453842 19503088)	Brain morphology (MOSTest) ( 32665545) Endometriosis ( 23104006 23472165 28537267) Pursuit maintenance gain ( 29064472)
Interacting Genes		31 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LIMK1 LMNA LRSAM1 MMGT1 NEK6 NEMP1 PGRMC2 PIGP POU6F2 PRDM16 PRKCZ SARDH SLC10A2 SPTAN1 SSMEM1 VEZT	16 interacting genes: ANKS6 AQP6 C5 CMTM3 CREB3L1 GORAB HSD17B11 LRRC4C MTIF3 MYO7A PGRMC2 RMDN2 SACM1L TLCD4 TMEM201 TSNARE1
Entrez ID		727	55591
HPRD ID		00405	11671
Ensembl ID		ENSG00000106804	ENSG00000028203
Uniprot IDs		P01031 Q59GS8	Q9HBM0
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT
Enriched GO Terms of Interacting Partners?
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