C5 and CPLX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		C5	CPLX4
Description		complement C5	complexin 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Exosome	Plasma Membrane SNARE Complex Terminal Bouton
	Molecular Function	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity	SNARE Binding Protein Binding Syntaxin Binding
	Biological Process	In Utero Embryonic Development Chemotaxis Inflammatory Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Positive Regulation Of Chemokine Production Positive Regulation Of Angiogenesis Cell Chemotaxis	Visual Perception Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Secretion Response To Stimulus
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24390342 20453842 19503088)	Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Macular thickness ( 30535121) Morning vs. evening chronotype ( 27494321)
Interacting Genes		31 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LIMK1 LMNA LRSAM1 MMGT1 NEK6 NEMP1 PGRMC2 PIGP POU6F2 PRDM16 PRKCZ SARDH SLC10A2 SPTAN1 SSMEM1 VEZT	92 interacting genes: ADIPOQ AGTRAP AIG1 AOC3 APOD AQP1 AQP9 ASGR1 ATP6V0C BNIP2 C14orf180 C1GALT1 C3orf52 C5 CACNG1 CCL4L2 CD81 CDIPT CDS2 CLDND2 CLEC4G CLN6 CMTM5 CNIH1 CTSA CTXN3 CYB5B CYBC1 CYP4F2 DEFB127 EMD GAD2 GIMAP1 GRM2 HACD1 HHATL HMOX1 INSIG2 LPAR3 MAL MALL MAN2B2 MGAM NINJ2 NRM ORMDL1 PGAP2 PLN PLP2 PLPP4 PNLIPRP1 PTPN9 RTP2 SEC22B SELENOK SFTPC SLC30A2 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC38A7 SLC39A9 SMCO4 STX3 STX8 SYNJ2BP TF TMEM120B TMEM14A TMEM14B TMEM19 TMEM201 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM267 TMEM60 TMEM79 TMEM86A TMEM97 TRAF3IP3 TSPO2 UBIAD1 VAMP4 VAMP5 VKORC1 WFDC2 YIPF6 ZFPL1
Entrez ID		727	339302
HPRD ID		00405	13091
Ensembl ID		ENSG00000106804	ENSG00000166569
Uniprot IDs		P01031 Q59GS8	Q7Z7G2
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT
Enriched GO Terms of Interacting Partners?
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