TRHR and TMEFF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TRHR	TMEFF2
Description		thyrotropin releasing hormone receptor	transmembrane protein with EGF like and two follistatin like domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Basement Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Thyrotropin-releasing Hormone Receptor Activity Protein Binding	Molecular_function Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway	Animal Organ Morphogenesis Tissue Development Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Wound Healing, Spreading Of Cells Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Stress Fiber Assembly
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Protirelin
Diseases
GWAS		Body mass (lean) ( 19268274) Daytime sleep phenotypes ( 27126917) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Pulse pressure ( 30224653) Type 2 diabetes ( 30297969)	Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diabetes (incident) ( 17903298) Schizophrenia ( 33169155) Sudden cardiac arrest ( 21658281)
Interacting Genes		19 interacting genes: ARRB1 C1QL4 COMT EFNA5 FAM241B FXYD6-FXYD2 GJB2 IER3IP1 NIPAL4 PEDS1-UBE2V1 SLC39A2 SLC39A9 SLC41A1 TMEFF2 TMEM218 TMEM239 TRH UBE2J1 YIPF6	12 interacting genes: DNAH7 DRD2 HSF2BP HTR4 NBPF19 NOTCH2NLA RIC3 STAT4 TMEM237 TRHR UBIAD1 ZDHHC15
Entrez ID		7201	23671
HPRD ID		11767	05760
Ensembl ID		ENSG00000174417	ENSG00000144339
Uniprot IDs		P34981	Q9UIK5
PDB IDs			2FMW
Enriched GO Terms of Interacting Partners?
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