TLR5 and RNF216

Number of citations of the paper that reports this interaction (PubMedID 15107846)
122

Data Source:
HPRD (two hybrid)

		TLR5	RNF216
Description		toll like receptor 5	ring finger protein 216
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	NAD+ Nucleosidase Activity Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding Protein Binding Signaling Receptor Activity	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Interleukin-8 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Defense Response To Bacterium Innate Immune Response Cellular Response To Mechanical Stimulus	Apoptotic Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission
Pathways		Toll Like Receptor 5 (TLR5) Cascade MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane	Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Monocyte percentage of white cells ( 32888494)	Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)
Interacting Genes		5 interacting genes: MYD88 RNF216 SIGIRR TLR1 TLR4	30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A
Entrez ID		7100	54476
HPRD ID		04326	15550
Ensembl ID		ENSG00000187554	ENSG00000011275
Uniprot IDs		A0A2R8Y7Z4 O60602	A8K8N1 Q9NWF9
PDB IDs		1P95 3J0A
Enriched GO Terms of Interacting Partners?
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