RNF216 and KIR2DL4

Number of citations of the paper that reports this interaction (PubMedID 21270397)
15

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RNF216	KIR2DL4
Description		ring finger protein 216	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transmembrane Signaling Receptor Activity Protein Binding MHC Class Ib Receptor Activity
	Biological Process	Apoptotic Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission	Positive Regulation Of Natural Killer Cell Cytokine Production Cellular Defense Response Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cellular Senescence
Pathways		Negative regulators of DDX58/IFIH1 signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)	Objective response to lithium treatment ( 26503763)
Interacting Genes		30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	9 interacting genes: BPIFA1 FCER1G FHL5 HLA-G INCA1 RBPMS RNF216 TIMMDC1 TRIP6
Entrez ID		54476	3805
HPRD ID		15550	16082
Ensembl ID		ENSG00000011275	ENSG00000189013
Uniprot IDs		A8K8N1 Q9NWF9	A0A0B4J1S6 A0A376A929 Q99706
PDB IDs			3WYR
Enriched GO Terms of Interacting Partners?
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