SERPING1 and SELP

Number of citations of the paper that reports this interaction (PubMedID 14568956)
24

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SERPING1	SELP
Description		serpin family G member 1	selectin P
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Lipopolysaccharide Binding Calcium Ion Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Complement Activation, Classical Pathway Aging Blood Coagulation Blood Circulation Negative Regulation Of Endopeptidase Activity Fibrinolysis Innate Immune Response	Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Response To Cytokine Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Gram-negative Bacterium Leukocyte Tethering Or Rolling Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade	Platelet degranulation Cell surface interactions at the vascular wall
Drugs		PPL-100 Copper	Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576 29875488 28240269) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Late-onset Alzheimer's disease ( 27770636) Monocyte count ( 32888494) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)
Interacting Genes		16 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2	11 interacting genes: AP1M1 CD24 EZR FCER1G FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN
Entrez ID		710	6403
HPRD ID		06033	01433
Ensembl ID		ENSG00000149131	ENSG00000174175
Uniprot IDs		E9KL26 P05155	A0A024R8Y9 P16109 Q5R341 Q6NUL9
PDB IDs		1M6Q 2OAY 5DU3 5DUQ	1FSB 1G1Q 1G1R 1G1S 1HES 1KJD
Enriched GO Terms of Interacting Partners?
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