SELP and GP1BA

Number of citations of the paper that reports this interaction (PubMedID 10499919)
65

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		SELP	GP1BA
Description		selectin P	glycoprotein Ib platelet subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Anchored Component Of External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Calcium Ion Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding	Protein Binding Thrombin-activated Receptor Activity
	Biological Process	Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Response To Cytokine Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Gram-negative Bacterium Leukocyte Tethering Or Rolling Positive Regulation Of Leukocyte Tethering Or Rolling	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Thrombin-activated Receptor Signaling Pathway Platelet Aggregation
Pathways		Platelet degranulation Cell surface interactions at the vascular wall	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation
Drugs		Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab	Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576 29875488 28240269) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Late-onset Alzheimer's disease ( 27770636) Monocyte count ( 32888494) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)	Blood protein levels ( 30072576 29875488) Keratoconus ( 33649486) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)
Interacting Genes		11 interacting genes: AP1M1 CD24 EZR FCER1G FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN	18 interacting genes: CTSG DDIT3 F11 F12 F2 FBXL4 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ
Entrez ID		6403	2811
HPRD ID		01433	01976
Ensembl ID		ENSG00000174175	ENSG00000185245
Uniprot IDs		A0A024R8Y9 P16109 Q5R341 Q6NUL9	L7UYB8 P07359
PDB IDs		1FSB 1G1Q 1G1R 1G1S 1HES 1KJD	1GWB 1K13 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6
Enriched GO Terms of Interacting Partners?
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