TIAL1 and MBNL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TIAL1	MBNL2
Description		TIA1 cytotoxic granule associated RNA binding protein like 1	muscleblind like splicing regulator 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Cytoplasmic Stress Granule Ribonucleoprotein Complex	Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding RNA Binding MRNA 3'-UTR Binding MRNA 3'-UTR AU-rich Region Binding MRNA Binding Involved In Posttranscriptional Gene Silencing	RNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Defense Response Germ Cell Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Posttranscriptional Gene Silencing Stem Cell Division Positive Regulation Of Hippo Signaling Positive Regulation Of Gene Silencing By MiRNA	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of RNA Splicing
Pathways		FGFR2 alternative splicing
Drugs
Diseases
GWAS		Depressive symptoms (stressful life events interaction) ( 27529621) Monocyte percentage of white cells ( 32888494) Parkinson's disease ( 27182965) Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) ( 27047539)	Alcoholism (alcohol dependence factor score) ( 21529783) Alcoholism (alcohol use disorder factor score) ( 21529783) Diastolic blood pressure ( 30224653) Energy expenditure (24h) ( 28476931) Lung function in heavy smokers (high FEV1 vs average FEV1) ( 26423011) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet reactivity in response to clopidogrel treatment ( 32472697) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		40 interacting genes: AKAP8L AOC1 BPIFA1 C10orf55 CAMK2A CELF4 CREBBP DAZAP2 FAM168A FAM168B FUBP1 GRINA INCA1 KLF1 KRTAP8-1 MAGED1 MAPK1 MAPK1IP1L MBNL2 MIR106A MIR106B MIR145 MIR199A1 MIR20A MIR29A MIR29C MIR34A MIR9-2 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RBPMS2 SMN1 SMN2 SNRPA VPS37C	2 interacting genes: SNRPA TIAL1
Entrez ID		7073	10150
HPRD ID		04563	09543
Ensembl ID		ENSG00000151923	ENSG00000139793
Uniprot IDs		Q01085 Q49AS9	A2A3S3 Q5VZF2
PDB IDs		1X4G 2CQI 2DH7	2E5S 2RPP
Enriched GO Terms of Interacting Partners?
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