THRB and MPG

Number of citations of the paper that reports this interaction (PubMedID 14761960)
31

Data Source:
HPRD (in vitro)

		THRB	MPG
Description		thyroid hormone receptor beta	N-methylpurine DNA glycosylase
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body	Nucleoplasm Cytosol Mitochondrial Nucleoid
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Thyroid Hormone Binding Sequence-specific Double-stranded DNA Binding	Damaged DNA Binding Alkylbase DNA N-glycosylase Activity Protein Binding DNA-3-methyladenine Glycosylase Activity DNA N-glycosylase Activity DNA-7-methylguanine Glycosylase Activity DNA-7-methyladenine Glycosylase Activity DNA-3-methylguanine Glycosylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Mediated Signaling Pathway Transcription, DNA-templated Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Hormone-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinal Cone Cell Development Type I Pneumocyte Differentiation Cellular Response To Thyroid Hormone Stimulus Retinal Cone Cell Apoptotic Process	Base-excision Repair DNA Dealkylation Involved In DNA Repair Depurination
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1
Drugs		Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid KB-141 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Tiratricol GC-24 Eprotirome MB07811 Sobetirome 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE Thyroid, porcine	Cisplatin Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis (sporadic) ( 24529757) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Colorectal cancer ( 34062886) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Extremely high intelligence ( 29520040) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 20139978 27863252 28017375) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 20139978 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myopia ( 27182965) Platelet distribution width ( 32888494) PR interval ( 32439900) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Relative wall thickness x antihypertensive treatment interaction ( 31407531) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure in sickle cell anemia ( 24058526) Triglyceride levels ( 32203549 32154731)	Blood protein levels ( 30072576) Glioblastoma ( 28346443) Hemoglobin levels ( 26366553) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell traits ( 23446634)
Interacting Genes		59 interacting genes: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PDE4DIP PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 UBE2I ZNHIT3	14 interacting genes: APP CRK EP300 ESR1 FBXO7 GPR182 HSD17B14 MLH1 RAD23A RAD23B RBFOX1 RXRA TERF2IP THRB
Entrez ID		7068	4350
HPRD ID		07521	06766
Ensembl ID		ENSG00000151090	ENSG00000103152
Uniprot IDs		A0A024R2I8 P10828	P29372 Q1W6H1
PDB IDs		1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1 6KKB 6KKE 6KNU 6KNV 6KNW	1BNK 1EWN 1F4R 1F6O 3QI5 3UBY
Enriched GO Terms of Interacting Partners?
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