THRA and SYAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		THRA	SYAP1
Description		thyroid hormone receptor alpha	synapse associated protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Axon Dendrite Growth Cone Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Presynaptic Membrane Perikaryon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein-containing Complex Binding Thyroid Hormone Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Mediated Signaling Pathway Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription, Initiation	Cell Differentiation Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus TORC2 Signaling Positive Regulation Of Fat Cell Differentiation Regulation Of Short-term Neuronal Synaptic Plasticity Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Cellular Response To Insulin-like Growth Factor Stimulus
Pathways		Nuclear Receptor transcription pathway
Drugs		Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix KB-141 Dronedarone Eprotirome NRP409 Thyroid, porcine
Diseases
GWAS		Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)
Interacting Genes		69 interacting genes: - AKAP13 AMOT AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CD160 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MEOX2 MTNR1B NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKAR1B PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 SYAP1 TACC1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3	7 interacting genes: ADIPOQ MIP OGT POT1 THRA TNFRSF10C ZFPL1
Entrez ID		7067	94056
HPRD ID		07185	06733
Ensembl ID		ENSG00000126351	ENSG00000169895
Uniprot IDs		P10827 Q6FH41	Q96A49
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX	1X3A
Enriched GO Terms of Interacting Partners?
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