THRA and CLIC1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		THRA	CLIC1
Description		thyroid hormone receptor alpha	chloride intracellular channel 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein-containing Complex Binding Thyroid Hormone Binding	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Mediated Signaling Pathway Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription, Initiation	Glutathione Metabolic Process Chloride Transport Signal Transduction Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Platelet Aggregation
Pathways		Nuclear Receptor transcription pathway
Drugs		Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix KB-141 Dronedarone Eprotirome NRP409 Thyroid, porcine	Copper Artenimol
Diseases
GWAS		Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)	Adult body size ( 32376654) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 27863252) Ulcerative colitis ( 28067908)
Interacting Genes		69 interacting genes: - AKAP13 AMOT AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CD160 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MEOX2 MTNR1B NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKAR1B PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 SYAP1 TACC1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3	24 interacting genes: AKAP9 ALOX5AP ATP5PB ATP6V0A1 ATP6V0C CPT1A DNAJC19 IKBKG LSM1 MEOX2 MYOC NHSL2 NTF4 NUP62 PCSK5 PRDX4 PSMD10 RPLP1 SUMO4 THRA TPRN TRAPPC2 ZNF184 ZNF302
Entrez ID		7067	1192
HPRD ID		07185	04188
Ensembl ID		ENSG00000126351	ENSG00000213719
Uniprot IDs		P10827 Q6FH41	O00299 Q53FB0 Q5SRT3
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX	1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA 4JZQ 4K0G 4K0N
Enriched GO Terms of Interacting Partners?
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