EXOC6 and NOS3

Number of citations of the paper that reports this interaction (PubMedID 21163940)
36

Data Source:
BioGRID (two hybrid)

		EXOC6	NOS3
Description		exocyst complex component 6	nitric oxide synthase 3
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytosol Plasma Membrane Membrane Growth Cone Perinuclear Region Of Cytoplasm Flemming Body	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Caveola Vesicle Membrane Endocytic Vesicle Membrane
	Molecular Function	Protein Binding	Actin Monomer Binding Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Intracellular Protein Transport Exocytosis Golgi To Plasma Membrane Transport Vesicle Tethering Involved In Exocytosis	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Endothelin Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis Arginine Catabolic Process Nitric Oxide Biosynthetic Process Mitochondrion Organization Nitric Oxide Mediated Signal Transduction Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Heat Response To Hormone Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Negative Regulation Of Muscle Hyperplasia Smooth Muscle Hyperplasia Removal Of Superoxide Radicals Positive Regulation Of Guanylate Cyclase Activity Regulation Of Nervous System Process Response To Lipopolysaccharide Response To Fluid Shear Stress Vasodilation Positive Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Biomineral Tissue Development Blood Vessel Diameter Maintenance Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling
Drugs			Arginine Citrulline Sapropterin Miconazole N,N-dimethylarginine L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide Canavanine 3-Bromo-7-Nitroindazole N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine N-[3-(aminomethyl)benzyl]acetamidine 1,2,4-Triazole-Carboxamidine L-N(omega)-nitroarginine-(4R)-amino-L-proline amide S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 7-Nitroindazole S-Ethylisothiourea 2-Aminothiazoline Se-Ethyl-Isoselenourea 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane Cacodylic acid 7-Nitroindazole-2-Carboxamidine 6-Nitroindazole N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine N(G)-Iminoethylornithine 5,6-Cyclic-Tetrahydropteridine S-Ethyl-N-Phenyl-Isothiourea S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 6S-5,6,7,8-Tetrahydrobiopterin S-(Dimethylarsenic)Cysteine L-homoarginine S-Isopropyl-Isothiourea Nitroarginine 5-Nitroindazole N-(Chlorophenyl)-N'-hydroxyguanidine (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Levamlodipine
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Body mass index ( 28892062) Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Glaucoma (primary open-angle) ( 29449654) Hemoglobin A1c levels ( 29403010) High density lipoprotein cholesterol levels ( 29403010 33339817) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 30054594) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Refractive error ( 32231278) Total bilirubin levels ( 29403010)	Coronary artery disease ( 29212778 30104761 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878 28739976 27618448) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31451708) Eyebrow thickness ( 26926045) Hypertension ( 27618448) Mean arterial pressure ( 27618448) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Stroke ( 30383316) Systolic blood pressure ( 27841878 27618448 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		12 interacting genes: APP CYP2C8 ECSIT EXOC5 EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32	48 interacting genes: A2M ACTN2 ACTN4 AGTR1 AKT1 APOE APP BDKRB2 BDNF CALM1 CAV1 CDC37 CEP55 EDNRB EFEMP1 EFEMP2 ELAVL1 ELAVL3 EXOC6 EXOSC1 FIS1 GCDH GOLGA2 H3-3A HSP90AA1 HTRA1 IKZF3 IMMT KANK2 MAGEA11 MAST1 MPRIP NMT1 NOSIP NOSTRIN PAXIP1 PI4K2A PPP2R5A PSEN1 PSEN2 RHEB RNF31 RNF32 SP1 ST13 TECR TXNDC11 UMPS
Entrez ID		54536	4846
HPRD ID		10216	01224
Ensembl ID		ENSG00000138190	ENSG00000164867
Uniprot IDs		A5YP36 B2RDH5 B3KXY5 B7Z6G5 E7EW84 Q8TAG9	A0S0A6 P29474
PDB IDs			1M9J 1M9K 1M9M 1M9Q 1M9R 1NIW 2LL7 2MG5 2N8J 3EAH 3NOS 4D1O 4D1P 5UO8 5UO9 5UOA 5UOB 5UOC 5VVB 5VVC 5VVD 5XOF 6AV6 6AV7 6CIE 6CIF 6NH1 6NH2 6NH3 6NH4 6NH5 6NH6 6NH7 6NH8 6NHF 6POU 6POV 6POW 6POX 6POY 6POZ 6PP0 6PP1 6PP2 6PP3 6PP4
Enriched GO Terms of Interacting Partners?
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