TCF21 and GTF3C5

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		TCF21	GTF3C5
Description		transcription factor 21	general transcription factor IIIC subunit 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Transcription Factor TFIIIC Complex Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity Androgen Receptor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Branching Structure Kidney Development Vasculature Development Regulation Of Transcription By RNA Polymerase II Sex Determination Branchiomeric Skeletal Muscle Development Epithelial Cell Differentiation Developmental Process Glomerulus Development Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Spleen Development Embryonic Digestive Tract Morphogenesis Reproductive Structure Development Gland Development Sertoli Cell Differentiation Roof Of Mouth Development Lung Morphogenesis Lung Vasculature Development Bronchiole Development Diaphragm Development Respiratory System Development Negative Regulation Of Androgen Receptor Signaling Pathway Metanephric Mesenchymal Cell Differentiation Metanephric Glomerular Capillary Formation	Transcription By RNA Polymerase III Transcription Initiation From RNA Polymerase III Promoter Skeletal Muscle Cell Differentiation 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways			RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Blood pressure traits (multi-trait analysis) ( 28498854) Blood urea nitrogen levels ( 31152163) Coronary artery disease ( 32469254 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 22751097 21378990) Diastolic blood pressure ( 28498854) Haemorrhoidal disease ( 33888516) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Pulse pressure ( 28498854) Systolic blood pressure ( 28498854)	Sepsis (28-day mortality) ( 32592749)
Interacting Genes		10 interacting genes: APEX1 APLP1 GTF3C5 HOXB6 KLF15 LMO4 MYOD1 SDCBP TCF12 TCF3	16 interacting genes: BRF1 DNMT3L GTF3C3 GTF3C4 GTF3C6 KRT40 KRTAP10-3 KRTAP12-3 MDFI NOTCH2NLA OGT PTEN SRA1 TBP TCF21 TCF4
Entrez ID		6943	9328
HPRD ID		04493	16077
Ensembl ID		ENSG00000118526	ENSG00000148308
Uniprot IDs		O43680	H7BY84 Q9Y5Q8
PDB IDs
Enriched GO Terms of Interacting Partners?
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