SYT4 and NDUFA12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SYT4	NDUFA12
Description		synaptotagmin 4	NADH:ubiquinone oxidoreductase subunit A12
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Golgi Membrane Integral Component Of Synaptic Vesicle Membrane Axon Dense Core Granule Membrane Neuronal Cell Body Neuron Projection Terminus Synapse Exocytic Vesicle Astrocyte Projection Intrinsic Component Of Neuronal Dense Core Vesicle Membrane Neuronal Dense Core Vesicle	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Cytosol
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin-1 Binding Clathrin Binding Syntaxin-3 Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Vesicle Fusion Brain Development Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Endocytosis Cell Differentiation Negative Regulation Of Vesicle Fusion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Neurotransmitter Secretion Vesicle Fusion With Vesicle Secretory Granule Maturation Cellular Response To Calcium Ion Dense Core Granule Cytoskeletal Transport Positive Regulation Of Dendrite Extension Negative Regulation Of Dense Core Granule Exocytosis	Response To Oxidative Stress Respiratory Gaseous Exchange By Respiratory System Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways			Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Body mass index ( 28892062 25673413) Carotid intima media thickness x smoking interaction ( 32117412) Ceramide levels (C24:0) ( 32489964) Coffee consumption ( 31046077) Metabolite levels ( 23823483) Parkinson's disease ( 28892059 21738487) Physical activity (moderate intensity activity duration) ( 30531941) Physical activity (overall physical activity time) ( 30531941) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Pulse pressure ( 27841878) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Brain morphology (MOSTest) ( 32665545) Chromosomal aberration frequency (chromosome type) ( 31586183) Coronary artery disease ( 32469254 29212778) Myocardial infarction ( 33532862)
Interacting Genes		12 interacting genes: NBR1 NDUFA12 NRXN1 SGTA SGTB STX1A STX2 STX3 STX4 SYNCRIP SYT1 TFAP2B	4 interacting genes: MYO15B SYT4 TMED8 ZNF768
Entrez ID		6860	55967
HPRD ID		02519	16781
Ensembl ID		ENSG00000132872	ENSG00000184752
Uniprot IDs		Q9H2B2	Q9UI09
PDB IDs		1UGK	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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