SYT4 and NBR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SYT4	NBR1
Description		synaptotagmin 4	NBR1 autophagy cargo receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Golgi Membrane Integral Component Of Synaptic Vesicle Membrane Axon Dense Core Granule Membrane Neuronal Cell Body Neuron Projection Terminus Synapse Exocytic Vesicle Astrocyte Projection Intrinsic Component Of Neuronal Dense Core Vesicle Membrane Neuronal Dense Core Vesicle	Phagophore Assembly Site Nucleoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Late Endosome Autophagosome Peroxisomal Membrane Cytosol Membrane Nuclear Body M Band Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin-1 Binding Clathrin Binding Syntaxin-3 Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Vesicle Fusion Brain Development Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Endocytosis Cell Differentiation Negative Regulation Of Vesicle Fusion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Neurotransmitter Secretion Vesicle Fusion With Vesicle Secretory Granule Maturation Cellular Response To Calcium Ion Dense Core Granule Cytoskeletal Transport Positive Regulation Of Dendrite Extension Negative Regulation Of Dense Core Granule Exocytosis	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation
Pathways			Pexophagy Pexophagy
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Body mass index ( 28892062 25673413) Carotid intima media thickness x smoking interaction ( 32117412) Ceramide levels (C24:0) ( 32489964) Coffee consumption ( 31046077) Metabolite levels ( 23823483) Parkinson's disease ( 28892059 21738487) Physical activity (moderate intensity activity duration) ( 30531941) Physical activity (overall physical activity time) ( 30531941) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Pulse pressure ( 27841878) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		12 interacting genes: NBR1 NDUFA12 NRXN1 SGTA SGTB STX1A STX2 STX3 STX4 SYNCRIP SYT1 TFAP2B	21 interacting genes: ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP2K4 METAP1 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1
Entrez ID		6860	4077
HPRD ID		02519	01326
Ensembl ID		ENSG00000132872	ENSG00000188554
Uniprot IDs		Q9H2B2	A0A024R1V3 B7Z5R6 Q14596
PDB IDs		1UGK	1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE
Enriched GO Terms of Interacting Partners?
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