STK11 and MAPRE1

Number of citations of the paper that reports this interaction (PubMedID 24552808)
18

Data Source:
BioGRID (two hybrid)

		STK11	MAPRE1
Description		serine/threonine kinase 11	microtubule associated protein RP/EB family member 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome	Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Microtubule Cytoplasmic Microtubule Focal Adhesion Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Ciliary Basal Body Spindle Midzone Mitotic Spindle Astral Microtubule End
	Molecular Function	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity Protein Serine Kinase Activity	RNA Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding
	Biological Process	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Protein Phosphorylation Protein Dephosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Spermatogenesis Axonogenesis Negative Regulation Of Cell Population Proliferation Response To Ionizing Radiation Positive Regulation Of Autophagy Establishment Of Cell Polarity Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Glucose Homeostasis Anoikis Positive Thymic T Cell Selection Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Golgi Localization Regulation Of Cell Cycle Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Canonical Wnt Signaling Pathway Dendrite Extension Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Vesicle Transport Along Microtubule Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling	Microtubule Bundle Formation Protein Localization Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Protein Localization To Centrosome Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end Non-motile Cilium Assembly
Pathways		AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Distal/Left-sided colorectal cancer ( 33632709) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900) Psychosis in Alzheimer's disease ( 22005930)	Brain morphology (MOSTest) ( 32665545) Iron status biomarkers (transferrin saturation) ( 28334935) Mean platelet volume ( 32888494) Oily fish consumption ( 32066663) Polycystic ovary syndrome ( 30566500) Pork consumption ( 32066663) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		140 interacting genes: ABCB5 ADIPOR1 AKT1 ALDOB ANP32B APP ARAF ARG2 ARNT ATM AURKA BAP1 BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCDC180 CCND2 CCNE1 CD44 CDC14B CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYLC2 CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FAM98B FBP1 FBP2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A HRAS IGFBP3 KAT2A KDELR2 KLK7 LATS2 LEF1 LYPD3 MADCAM1 MAP2K1 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPK3 MAPRE1 MARK1 MARK2 MARK4 MDM2 MET MOB4 MOCS2 MT-ND2 MYC NANS NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PPP2CB PPP6R1 PRKAA1 PRKAA2 PRKACA PRSS50 PTEN RASA1 RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SERPINB5 SH3GL1 SIK1 SIRT1 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB STX17 TBC1D23 TDRD7 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TRMO TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 XPA YWHAG ZNF189 ZNF195 ZNF510	51 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 C20orf202 CASK CCSER1 CDC42 CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GAS2L2 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL12 KLHL21 KNSTRN LMO2 LRP1 MACF1 MARCHF7 MEOX2 NAV1 NUPR1 PAX6 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SPDYE2B SRC SRPK2 STK11 TERF1 TRAF2 TUBA1A TUBB ZNF653
Entrez ID		6794	22919
HPRD ID		03740	04379
Ensembl ID		ENSG00000118046	ENSG00000101367
Uniprot IDs		A0A0S2Z4D1 Q15831	Q15691
PDB IDs		2WTK 4ZDR 5WXN	1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ 6PF2 6PFP 6YF5 6YSH
Enriched GO Terms of Interacting Partners?
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