AURKA and USP2

Number of citations of the paper that reports this interaction (PubMedID 21890637)
29

Data Source:
BioGRID (enzymatic study)

		AURKA	USP2
Description		aurora kinase A	ubiquitin specific peptidase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Centriole Spindle Cytosol Spindle Microtubule Cilium Microtubule Cytoskeleton Midbody Spindle Pole Centrosome Chromosome Passenger Complex Germinal Vesicle Axon Hillock Pronucleus Perinuclear Region Of Cytoplasm Spindle Midzone Meiotic Spindle Mitotic Spindle Pole	Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Serine Kinase Activity Protein Heterodimerization Activity Protein Serine Kinase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Mitotic Centrosome Separation Response To Wounding Anterior/posterior Axis Specification Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Peptidyl-serine Phosphorylation Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Histone-serine Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Cycle Protein Autophosphorylation Cell Division Centrosome Localization Protein Localization To Centrosome Positive Regulation Of Mitochondrial Fission Liver Regeneration Positive Regulation Of Oocyte Maturation Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Extension	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of PLK1 Activity at G2/M Transition SUMOylation of DNA replication proteins TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation FBXL7 down-regulates AURKA during mitotic entry and in early mitosis AURKA Activation by TPX2 Interaction between PHLDA1 and AURKA	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation
Drugs		Phosphonothreonine AT9283 CYC116 Alisertib SNS-314 Cenisertib Enzastaurin 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE AKI-001 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE Fostamatinib MLN8054
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 31985003 31578528 23263486)
Interacting Genes		170 interacting genes: AATF AKT1 ANGPTL4 ANP32B APP ARPC1B ARPC2 ATRX AUNIP AURKAIP1 BAAT BCL2L1 BEX2 BIRC5 BLID BORA BRAF BRCA1 BTK CBX3 CCND2 CCNE1 CDC20 CDC25B CDH13 CDK8 CHFR CKAP5 CORO2A CSN2 CTCFL CYLC2 DACH1 DKK3 EHMT2 EPHA2 EPSTI1 ERBB2 ERRFI1 FANCA FBP2 FOXF1 FOXP1 FZR1 GADD45A GMNN GSK3B GTF3C4 H3-4 H3C1 HDAC2 HDAC6 HEMGN HIF1A HNRNPF HNRNPK IFI16 IGFBP3 IKBKB INCENP KIF11 KIF2C KLHL18 KLK5 LATS2 LEF1 LYPD3 MAP2K1 MAP2K3 MAP3K5 MAPK3 MAPRE2 MAPRE3 MBD3 MBP MDM2 MED26 MTA3 MYC MYT1 MYT1L NANS NAT2 NDC80 NEDD9 NF2 NFKBIA NFXL1 NIN NKX1-1 NME1 NSD2 NUF2 OTUB1 OTUD7B PARP10 PAX4 PAX8 PDGFRA PDLIM2 PLK3 PML POU4F3 PPP1CA PPP1CB PPP1CC PPP2CB PPP3R2 PRKACA PSEN2 PSMC3IP PTPRD PTTG1 PUM2 RASA1 RASSF1 RELA REST S100A14 SCGB3A1 SEC61B SFRP4 SIN3B SOX18 SOX3 SOX30 SOX4 SREBF2 SRPK1 SRPK2 SSRP1 STAT2 STK11 STX17 SUPT20H SWT1 TACC1 TACC3 TBC1D2 TBX10 TCEAL2 TCERG1 TCF3 TEAD2 TFAP2B TGFB1 THRSP TLK1 TLK2 TP53 TP73 TPX2 TRMO TRRAP TSC1 TSTD2 UBE2C UBE2I UBE2N UBTF USP2 USP21 VHL WIF1 XPA YY1 ZFHX3 ZKSCAN2 ZNF189 ZNF510	165 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP ASPG ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BHLHB9 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CCND1 CDC34 CEP63 CEP70 CRACR2A CRACR2B CRY1 DDI1 DEPDC5 DISC1 DTX3 DUSP21 DYDC1 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 FANCD2 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GRB7 GRIPAP1 H2AC20 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PCNA PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF166 RUNDC3A S100A10 SH2B2 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBC UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1
Entrez ID		6790	9099
HPRD ID		04066	05287
Ensembl ID		ENSG00000087586	ENSG00000036672
Uniprot IDs		O14965	O75604
PDB IDs		1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 3W10 3W16 3W18 3W2C 4B0G 4BN1 4BYI 4BYJ 4C3P 4C3R 4CEG 4DEA 4DEB 4DED 4DEE 4DHF 4J8M 4J8N 4JAI 4JAJ 4JBO 4JBP 4JBQ 4O0S 4O0U 4O0W 4PRJ 4UYN 4UZD 4UZH 4ZS0 4ZTQ 4ZTR 4ZTS 5AAD 5AAE 5AAF 5AAG 5DN3 5DNR 5DOS 5DPV 5DR2 5DR6 5DR9 5DRD 5DT0 5DT3 5DT4 5EW9 5G15 5G1X 5L8J 5L8K 5L8L 5LXM 5OBJ 5OBR 5ODT 5ONE 5ORL 5ORN 5ORO 5ORP 5ORR 5ORS 5ORT 5ORV 5ORW 5ORX 5ORY 5ORZ 5OS0 5OS1 5OS2 5OS3 5OS4 5OS5 5OS6 5OSD 5OSE 5OSF 5ZAN 6C2R 6C2T 6C83 6CPE 6CPF 6CPG 6GRA 6HJJ 6HJK 6I2U 6R49 6R4A 6R4B 6R4C 6R4D 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA 6Z4Y 7AYH 7AYI	2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF
Enriched GO Terms of Interacting Partners?
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