USP2 and RNF125

Number of citations of the paper that reports this interaction (PubMedID 23105109)
19

Data Source:
BioGRID (two hybrid)

		USP2	RNF125
Description		ubiquitin specific peptidase 2	ring finger protein 125
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm	Golgi Membrane VCP-NPL4-UFD1 AAA ATPase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding	P53 Binding Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator	Protein Polyubiquitination Adaptive Immune Response Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Cellular Response To Leukemia Inhibitory Factor
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation	Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 31985003 31578528 23263486)
Interacting Genes		165 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP ASPG ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BHLHB9 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CCND1 CDC34 CEP63 CEP70 CRACR2A CRACR2B CRY1 DDI1 DEPDC5 DISC1 DTX3 DUSP21 DYDC1 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 FANCD2 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GRB7 GRIPAP1 H2AC20 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PCNA PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF166 RUNDC3A S100A10 SH2B2 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBC UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1	26 interacting genes: BHLHA9 CHFR EFHC1 FNDC11 MYOZ3 PCGF1 PML PNMA6A SPAG8 TP53 TRIM14 TRIM46 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2L6 UBE2N UBE2U UBE2W USP2 ZNF414
Entrez ID		9099	54941
HPRD ID		05287	11500
Ensembl ID		ENSG00000036672	ENSG00000101695
Uniprot IDs		O75604	Q96EQ8
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF	5DKA
Enriched GO Terms of Interacting Partners?
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