MMP2 and TIMP3

Number of citations of the paper that reports this interaction (PubMedID 7782289)
57

Data Source:
HPRD (in vitro)

		MMP2	TIMP3
Description		matrix metallopeptidase 2	TIMP metallopeptidase inhibitor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding	Protease Binding Protein Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Tissue Remodeling Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus Cellular Response To UV-A Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Visual Perception Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling	Platelet degranulation
Drugs		Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin	Pimagedine
Diseases
GWAS		Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Alzheimer's disease progression score ( 29860282) Blood protein levels ( 28240269) Metabolite levels ( 23823483) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 31170924)
Interacting Genes		39 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	8 interacting genes: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9
Entrez ID		4313	7078
HPRD ID		00386	01785
Ensembl ID		ENSG00000087245	ENSG00000100234
Uniprot IDs		A0A024R6R4 P08253	P35625
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU	3CKI
Enriched GO Terms of Interacting Partners?
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