DST and DCTN1

Number of citations of the paper that reports this interaction (PubMedID 14581450)
29

Data Source:
HPRD (in vivo)

		DST	DCTN1
Description		dystonin	dynactin subunit 1
Image
GO Annotations	Cellular Component	Basement Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Intermediate Filament Focal Adhesion Cell Cortex Basal Plasma Membrane Microtubule Cytoskeleton Membrane Integral Component Of Membrane Z Disc Hemidesmosome Cell Leading Edge Cytoplasmic Vesicle H Zone Microtubule Plus-end Axon Cytoplasm	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Microtubule Plus-end Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage
	Molecular Function	Actin Binding Integrin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Protein C-terminus Binding Microtubule Plus-end Binding	Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding Microtubule Plus-end Binding
	Biological Process	Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Retrograde Axonal Transport Response To Wounding Maintenance Of Cell Polarity Cytoplasmic Microtubule Organization Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization Cell Motility	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Migration Nervous System Development Neuromuscular Junction Development Centriole-centriole Cohesion Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Membrane Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance
Pathways		Type I hemidesmosome assembly RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Attention function in attention deficit hyperactive disorder ( 26174813) Cerebrospinal fluid clusterin levels ( 26545630) Daytime sleep phenotypes ( 27126917) Gout (normal type) ( 32238385) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494) Small cell lung carcinoma ( 28604730)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Refractive error ( 32231278)
Interacting Genes		38 interacting genes: ABI1 ANKRD1 APC BMP1 C1QTNF9 CALM1 CDC5L CELSR3 CEP63 CLIP4 COL17A1 DCTN1 DISC1 DTNBP1 ECPAS ERBB2 ERBIN EXOC1 ITGB4 ITSN2 KIAA1549 KRT14 KRT5 LINC01554 MAPK6 MTNR1B MYBPC2 NFYC PAK2 PRKAB2 PRKD2 PTGER4 SH3BP5 SMAD9 SNAPIN TNIK TRAF3IP1 TULP3	51 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 ENO3 FBXL5 FXR1 GRB2 GSK3B HAP1 HOXA1 HSPB2 KIAA0408 KIF11 KMT2A KRT5 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TMED5 TP53RK VIM ZNF512B
Entrez ID		667	1639
HPRD ID		00222	07206
Ensembl ID		ENSG00000151914	ENSG00000204843
Uniprot IDs		B4DGY0 B4DSS9 E9PHM6 F6QMI7 Q03001 Q6P0N6	Q14203 Q6MZZ3
PDB IDs		3GJO	1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?
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