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DCTN1 and NOD2
Number of citations of the paper that reports this interaction (PubMedID
27812135
)
4
Data Source:
BioGRID
(two hybrid)
DCTN1
NOD2
Description
dynactin subunit 1
nucleotide binding oligomerization domain containing 2
Image
No pdb structure
GO Annotations
Cellular Component
Kinetochore
Spindle Pole
Nucleus
Nuclear Envelope
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Microtubule
Microtubule Associated Complex
Cell Cortex
Microtubule Cytoskeleton
Membrane
Dynein Complex
Axon
Microtubule Plus-end
Neuron Projection
Neuronal Cell Body
Intercellular Bridge
Mitotic Spindle
Cell Cortex Region
Centriolar Subdistal Appendage
Cytoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Vesicle
Protein-containing Complex
Phagocytic Vesicle
Anchored Component Of Plasma Membrane
Molecular Function
Protein Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Tau Protein Binding
Microtubule Plus-end Binding
Actin Binding
Protein Binding
ATP Binding
Enzyme Binding
Protein Kinase Binding
Hsp70 Protein Binding
Muramyl Dipeptide Binding
Pattern Recognition Receptor Activity
Peptidoglycan Binding
Protein-containing Complex Binding
CARD Domain Binding
Hsp90 Protein Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Nuclear Migration
Nervous System Development
Neuromuscular Junction Development
Centriole-centriole Cohesion
Ventral Spinal Cord Development
Positive Regulation Of Microtubule Polymerization
Cytoplasmic Microtubule Organization
Microtubule Anchoring At Centrosome
Retrograde Transport, Endosome To Golgi
Neuromuscular Process
Nuclear Membrane Disassembly
Cell Division
Regulation Of Mitotic Spindle Organization
Motor Behavior
Neuron Cellular Homeostasis
Positive Regulation Of Microtubule Nucleation
Axonal Transport
Maintenance Of Synapse Structure
Positive Regulation Of Neuromuscular Junction Development
Non-motile Cilium Assembly
Neuron Projection Maintenance
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response In Mucosa
Activation Of Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of T Cell Mediated Immunity
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Cytokine Production
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Defense Response
Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria
Response To Nutrient
Detection Of Biotic Stimulus
Detection Of Bacterium
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Detection Of Muramyl Dipeptide
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-18 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Intracellular Signal Transduction
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Gamma-delta T Cell Activation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Oxidoreductase Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Peptidoglycan
Cellular Response To Muramyl Dipeptide
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Xenophagy
Negative Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
XBP1(S) activates chaperone genes
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Signaling by ALK fusions and activated point mutants
NOD1/2 Signaling Pathway
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling
Drugs
Mifamurtide
Diseases
GWAS
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Refractive error (
32231278
)
Asthma (
31361310
30929738
32296059
)
Asthma (childhood onset) (
31036433
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
20570966
22936669
22412388
17554300
21102463
23128233
17804789
)
Inflammatory bowel disease (
18758464
28067908
)
Leprosy (
20018961
27976721
25642632
)
Medication use (thyroid preparations) (
31015401
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Interacting Genes
51 interacting genes:
ACTR1A
ACTR1B
AKT1
APEX1
BBS1
BBS4
BICD1
BICD2
CASP2
CASP3
CASP7
CDC37
CLIP1
DCTN3
DISC1
DST
DTNBP1
DYNC1I2
ENO3
FBXL5
FXR1
GRB2
GSK3B
HAP1
HOXA1
HSPB2
KIAA0408
KIF11
KMT2A
KRT5
MAP2K3
MAP2K6
MAPRE1
MED14
MTERF1
NEK2
NOD2
PAFAH1B1
PFDN1
PGAM1
PPP1CA
RAB6A
RBL2
RPGR
SEC23A
SPTBN2
STAT1
TMED5
TP53RK
VIM
ZNF512B
40 interacting genes:
ALPI
ANKHD1
ANXA2
ATG16L1
C10orf67
CCL13
CHMP4B
CHMP5
CNOT1
DCTN1
DOCK7
ENTR1
ERBIN
GOLGA6L5P
GOLGB1
HAP1
IKBIP
IRGM
LDOC1
LMNA
LURAP1L
MAP3K7
NLRC4
PDLIM5
PPP1R12C
PPP2R3B
PRR16
RIPK2
RPL13A
SCYL1
SETD6
TACC3
TNIP1
TPM1
TPM3
TPM4
TRIM41
VCP
WBP11
XIAP
Entrez ID
1639
64127
HPRD ID
07206
05810
Ensembl ID
ENSG00000204843
ENSG00000167207
Uniprot IDs
Q14203
Q6MZZ3
A0A286YF65
Q9HC29
PDB IDs
1TXQ
2COY
2HKN
2HKQ
2HL3
2HL5
2HQH
3E2U
3TQ7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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