SNRPB and IL7R

Number of citations of the paper that reports this interaction (PubMedID 23151878)
15

Data Source:
BioGRID (unspecified method)

		SNRPB	IL7R
Description		small nuclear ribonucleoprotein polypeptides B and B1	interleukin 7 receptor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Telomerase Holoenzyme Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	RNA Binding Protein Binding Telomerase RNA Binding Histone Pre-mRNA DCP Binding U1 SnRNP Binding U2 SnRNP Binding	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Protein Methylation Brain Development RNA Splicing	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Positive Regulation Of Gene Expression T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells Defense Response To Gram-positive Bacterium Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Eczema ( 31361310) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Primary biliary cholangitis ( 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)
Interacting Genes		90 interacting genes: AKAP9 ASCC2 BAG4 BANP C10orf55 CALCOCO2 CD2BP2 CDKN2A CEP55 CLNS1A COA7 COG6 COIL CREM CTDP1 CYSRT1 DAB1 DDX20 DHX9 ERG28 EXOSC8 FAM168B FBN2 FHL3 FNBP4 FUBP1 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GIGYF1 GIGYF2 GOLGA2 HNRNPH1 HOXA1 IL7R INCA1 KRT34 KRT40 KRTAP19-1 KRTAP19-6 KRTAP6-1 KRTAP6-2 KRTAP6-3 L3MBTL3 LSM11 LSM8 MAGI2 MBD3L1 OIP5 OOEP PFDN5 PLEKHB2 PNMA1 PRMT5 PRMT7 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 PSMA3 RBPMS RFX6 SERTAD3 SKIV2L SMN1 SMN2 SMNDC1 SNRPD1 SNRPD3 SNUPN SP3 SPAG8 SS18L1 STRAP STXBP2 STXBP3 TFIP11 TOP3B TRAF4 TRIM23 UBQLN2 UBXN11 USP54 WBP4 WDR77 WWP2 ZNF143	110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		6628	3575
HPRD ID		01655	00893
Ensembl ID		ENSG00000125835	ENSG00000168685
Uniprot IDs		P14678 Q66K91	P16871
PDB IDs		1D3B 3CW1 3JCR 3PGW 4PJO 4WZJ 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6V4X 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y	3DI2 3DI3 3UP1 5J11 6P50 6P67
Enriched GO Terms of Interacting Partners?
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