IL7R and ILF3

Number of citations of the paper that reports this interaction (PubMedID 23151878)
15

Data Source:
BioGRID (unspecified method)

		IL7R	ILF3
Description		interleukin 7 receptor	interleukin enhancer binding factor 3
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Membrane Ribonucleoprotein Complex
	Molecular Function	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Positive Regulation Of Gene Expression T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells Defense Response To Gram-positive Bacterium Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT	Protein Phosphorylation Negative Regulation Of Translation Negative Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Defense Response To Virus
Pathways		Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Eczema ( 31361310) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Primary biliary cholangitis ( 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)	Bipolar disorder ( 31043756) Chronotype ( 30696823) Height ( 25282103 25429064) Ischemic stroke ( 29531354) Obesity-related traits ( 23251661) Psoriasis ( 25903422 25574825 23143594) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 30423114) Stroke ( 29531354) Systemic lupus erythematosus ( 28714469)
Interacting Genes		110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787	40 interacting genes: DHX9 DUX4 EIF2AK2 EP300 ERBB2 ERG ESR1 FUS GDF9 HNRNPH2 IL7R KRTAP4-12 LNX1 MAGEA11 MAPK1 MDFI NDRG1 OGT PLSCR1 PPP1R12A PRMT1 PRMT5 PTEN RBM5 RBPMS RNF113A SF1 SF3B4 SMN1 SNRPC SPOP TRIM55 TRIM63 TRIP6 UBC VPS37C XAB2 XPO5 ZNF346 ZNF830
Entrez ID		3575	3609
HPRD ID		00893	04420
Ensembl ID		ENSG00000168685	ENSG00000129351
Uniprot IDs		P16871	A0A024R7C7 Q12906
PDB IDs		3DI2 3DI3 3UP1 5J11 6P50 6P67	2L33 3P1X
Enriched GO Terms of Interacting Partners?
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