POLR3D and MAPK11

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		POLR3D	MAPK11
Description		RNA polymerase III subunit D	mitogen-activated protein kinase 11
Image
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase III Complex Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding DNA-directed 5'-3' RNA Polymerase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Transcription By RNA Polymerase III Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus	Osteoblast Differentiation Protein Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Cellular Response To Interleukin-1 Cellular Senescence Cellular Response To Virus
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation
Drugs			Minocycline KC706 Regorafenib
Diseases
GWAS		Hypertriglyceridemia ( 23505323)	Acne (severe) ( 24927181) Adult body size ( 32376654)
Interacting Genes		14 interacting genes: APEX1 ATF3 HNRNPAB HOXA10 HOXC9 MAPK11 MSX2 NR2E3 OGT POLR3E RBFOX2 RHOXF2 TAB1 ZNF496	27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1
Entrez ID		661	5600
HPRD ID		01755	04208
Ensembl ID		ENSG00000168495	ENSG00000185386
Uniprot IDs		P05423	Q15759
PDB IDs		7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59	3GC8 3GC9 3GP0
Enriched GO Terms of Interacting Partners?
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