SMARCC1 and PTH1R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMARCC1	PTH1R
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	parathyroid hormone 1 receptor
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GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Cytoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding Protein N-terminus Binding	Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity Protein Self-association
	Biological Process	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Prostate Gland Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Skeletal System Development In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Cellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Abaloparatide Parathyroid hormone Teriparatide
Diseases
GWAS		Age at first birth ( 34211149) Household income (MTAG) ( 31844048) Renal underexcretion gout ( 32238385) Systolic blood pressure ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Birth weight ( 31043758 27680694) Hip circumference adjusted for BMI ( 34021172) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		54 interacting genes: ADAMTSL4 ADD1 AKT1 CCNE1 CEBPB CFP CIDEB CYSRT1 EWSR1 FANCA FUS GATA1 GLRX3 GSTO2 ITCH KLF1 KRTAP13-3 KRTAP19-2 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LRP2BP MGAT5B MSL1 MYC NCOA1 NEDD4 NONO NR3C1 OTX1 PLSCR1 PPIP5K2 PRMT5 PTH1R RELB SIN3A SLC15A2 SMARCA4 SMARCD3 SP1 SPATA12 STT3B TAF15 TRIM42 UFSP1 VGLL3 ZNF581	16 interacting genes: ARRB1 GNB1 GPANK1 GUCD1 HOXA1 MGAT5B MKRN3 PTH PTHLH SLC9A3R1 SLC9A3R2 SMARCC1 STK16 TEKT4 UBC YWHAH
Entrez ID		6599	5745
HPRD ID		03435	01347
Ensembl ID		ENSG00000173473	ENSG00000160801
Uniprot IDs		Q58EY4 Q92922	A1LPH3 Q03431 Q0VGD7
PDB IDs		2YUS 5GJK 6KZ7	1BL1 1ET2 1ET3 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI
Enriched GO Terms of Interacting Partners?
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