PTH1R and GNB1

Number of citations of the paper that reports this interaction (PubMedID 16099817)
28

Data Source:
HPRD (in vitro)

		PTH1R	GNB1
Description		parathyroid hormone 1 receptor	G protein subunit beta 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex	Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Photoreceptor Outer Segment Membrane Cell Body Synapse Extracellular Exosome Photoreceptor Disc Membrane Extracellular Vesicle
	Molecular Function	Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity Protein Self-association	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Spectrin Binding Protein-containing Complex Binding Alkylglycerophosphoethanolamine Phosphodiesterase Activity GTPase Binding
	Biological Process	Skeletal System Development In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Cellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Acetylcholine Receptor Signaling Pathway Ras Protein Signal Transduction Cell Population Proliferation Cardiac Muscle Cell Apoptotic Process Sensory Perception Of Taste Retina Development In Camera-type Eye Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Catecholamine Stimulus
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Abaloparatide Parathyroid hormone Teriparatide
Diseases
GWAS		Birth weight ( 31043758 27680694) Hip circumference adjusted for BMI ( 34021172) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Body mass index ( 26426971 25673413) Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		16 interacting genes: ARRB1 GNB1 GPANK1 GUCD1 HOXA1 MGAT5B MKRN3 PTH PTHLH SLC9A3R1 SLC9A3R2 SMARCC1 STK16 TEKT4 UBC YWHAH	46 interacting genes: ADRA2A ADRB2 AFP ARHGEF18 ATXN10 AVPR2 BTK CACNA1A CACNA1B CACNA1C CDC42 CTNNA3 CYFIP1 DISC1 EPHA7 EXOC5 GNA12 GNAS GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 HDAC5 KCNJ3 MCF2 MRGPRX1 MTNR1A MTNR1B NOL11 NR3C1 PDCL PTH1R RACK1 RASD1 RASD2 SLC35E2A SSU72 TBXA2R VAC14
Entrez ID		5745	2782
HPRD ID		01347	00766
Ensembl ID		ENSG00000160801	ENSG00000078369
Uniprot IDs		A1LPH3 Q03431 Q0VGD7	A0A140VJJ8 B3KVK2 P62873
PDB IDs		1BL1 1ET2 1ET3 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI	4KFM 4PNK 5HE0 5HE1 5HE2 5HE3 5UKK 5UKL 5UKM 5UZ7 6B3J 6CRK 6D9H 6DDE 6DDF 6E3Y 6EG8 6G79 6GDG 6KPF 6KPG 6LFM 6LFO 6LI3 6LMK 6LML 6M1H 6M1I 6M8S 6N4B 6NI3 6NIY 6OIJ 6OIK 6OMM 6ORV 6OS9 6OSA 6OT0 6P9X 6P9Y 6PB0 6PB1 6PT0 6UUN 6UUS 6UVA 6VCB 6VMS 6VN7 6WHA 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 6XBJ 6XBK 6XBL 6XBM 6XOX 7C2E 7CFM 7CFN 7CKW 7CKX 7CKY 7CKZ 7CRH 7D76 7D77 7D7M 7JV5 7JVP 7JVQ 7JVR 7K7L 7K7Z 7L0P 7L0Q 7L0R 7L0S 7L1U 7L1V 7LCI
Enriched GO Terms of Interacting Partners?
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