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SMURF1 and TLN1
Number of citations of the paper that reports this interaction (PubMedID
19363486
)
100
Data Source:
BioGRID
(pull down, affinity chromatography technology)
SMURF1
TLN1
Description
SMAD specific E3 ubiquitin protein ligase 1
talin 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Axon
Neuronal Cell Body
Extracellular Exosome
Ruffle
Extracellular Region
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Focal Adhesion
Cell Surface
Ruffle Membrane
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Phospholipid Binding
Activin Binding
Ubiquitin Protein Ligase Activity
I-SMAD Binding
R-SMAD Binding
Phosphatidylserine Binding
Integrin Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Vinculin Binding
LIM Domain Binding
Phosphatidylinositol Binding
Cadherin Binding
Actin Filament Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Export From Nucleus
Ectoderm Development
Protein Ubiquitination
Cell Differentiation
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Receptor Catabolic Process
Protein Localization To Cell Surface
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Engulfment Of Target By Autophagosome
Substrate Localization To Autophagosome
Protein Targeting To Vacuole Involved In Autophagy
Protein Localization To Plasma Membrane
Positive Regulation Of Dendrite Extension
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Cell-cell Junction Assembly
Cell-substrate Junction Assembly
Integrin-mediated Signaling Pathway
Cortical Actin Cytoskeleton Organization
Integrin Activation
Platelet Aggregation
Cell-cell Adhesion
Pathways
Signaling by BMP
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Asymmetric localization of PCP proteins
Hedgehog 'on' state
Hedgehog 'on' state
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Platelet degranulation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
XBP1(S) activates chaperone genes
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Smooth Muscle Contraction
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Diseases
GWAS
Facial emotion recognition (sad faces) (
28608620
)
Inflammatory bowel disease (
28067908
23128233
)
Lack of premeditation (
30718321
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Ulcerative colitis (
28067908
20228798
)
Brain morphology (MOSTest) (
32665545
)
IgE levels in asthmatics (
23967269
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Interacting Genes
191 interacting genes:
ADRM1
ANAPC5
ANKRD13A
ANKRD13D
ANKRD50
ANKS4B
ANXA6
AP2B1
APBB2
APP
ARHGAP15
ARHGAP31
ARHGEF9
ARL14
ARL4D
ASCC2
ASH2L
ATXN3
AVEN
AXIN1
BMPR2
BTK
BTRC
C9orf78
CALCOCO1
CCDC69
CCM2
CDC40
CDK14
CDKL1
CSNK1D
CSNK2A2
CTNNB1
CTNND1
CTTN
CUEDC1
CUL5
CXXC1
DDX54
DNAJC7
DUSP13
DVL2
ECSIT
ELOF1
ELP3
ENTR1
EPHA1
EPN1
ETV6
FAF2
FBXL15
FBXO3
FBXO30
FCHO1
FES
FGF12
FGR
FKBP3
FSCN1
FZR1
GNG11
GRIPAP1
GRK3
HDGFL3
HIP1
HOMER2
ILRUN
IMPACT
ING2
INPP5B
IRAK2
ITGB1BP1
ITK
JUNB
KRT36
LATS1
LCK
LHX9
LIMS1
LMNA
LONRF3
MAP3K10
MAP3K2
MAP3K3
MAP3K9
MAP4K5
MARK2
MATK
MEPCE
MINDY3
MSN
NAA16
NDFIP2
NEDD8
NEK2
NSD2
ODF2
OTUD6B
OXSR1
PADI4
PAK1
PAK1IP1
PDGFRA
PDLIM7
PICALM
PIP5K1C
PLEKHO1
POLR2A
PRKCA
PRKCG
PRKCI
PRR16
PSMD4
PSME3
PTEN
PWP1
RABEP1
RAD23A
RASD2
RBCK1
RHOA
RHOB
RHPN2
RIOK3
RIPK2
RIT1
RNF11
RNF114
RNF141
RPS27A
RRP9
RTKN
RUNX3
SASH3
SCYL1
SENP8
SF3A1
SLAIN2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SPART
SQSTM1
SRSF4
SRSF5
STK31
STK35
STRAP
STUB1
TAB1
TAOK3
TBK1
TLN1
TNIK
TNIP2
TNK2
TNNT1
TOM1
TOM1L2
TPM4
TRAF4
TRIP10
TTC17
UBA52
UBAC1
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2G1
UBE2K
UBE2L3
UBE2M
UBE2V1
UBQLN1
UBQLN2
UBTF
UBXN1
UBXN6
UBXN7
USP45
USP9X
WDR61
WEE1
WFS1
XPO1
ZFAND5
31 interacting genes:
ABI1
ACTA1
AZIN2
CCL19
CDK5
DAG1
DOK1
EGFR
ERBB2
HSP90AA1
ITGA1
ITGA2B
ITGB1
ITGB2
ITGB3
ITGB5
ITGB7
LRP2
MTNR1A
MTNR1B
NRAP
PKD1
PTK2
PTK2B
PXN
SMURF1
SUMO2
TES
TUBA1A
VCL
YWHAQ
Entrez ID
57154
7094
HPRD ID
06902
01726
Ensembl ID
ENSG00000198742
ENSG00000137076
Uniprot IDs
Q9HCE7
Q9Y490
PDB IDs
2LAZ
2LB0
2LB1
2LTX
3PYC
1SYQ
2MWN
4DJ9
6R9T
Enriched GO Terms of Interacting Partners
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