SLC6A3 and AHRR

		SLC6A3	AHRR
Description		solute carrier family 6 member 3	aryl-hydrocarbon receptor repressor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Flotillin Complex Axon Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Neuronal Cell Body Membrane Raft Dopaminergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Chromatin Nucleus Nucleoplasm Cytosol Aryl Hydrocarbon Receptor Complex
	Molecular Function	Protease Binding Signaling Receptor Binding Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Dopamine Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding Protein Phosphatase 2A Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Neurotransmitter Transport Aging Lactation Sensory Perception Of Smell Locomotory Behavior Response To Xenobiotic Stimulus Response To Iron Ion Monoamine Transport Dopamine Transport Norepinephrine Transport Adenohypophysis Development Response To Nicotine Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Neurotransmitter Biosynthetic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Ethanol Dopamine Uptake Involved In Synaptic Transmission Response To CAMP Norepinephrine Uptake Prepulse Inhibition Dopamine Uptake Hyaloid Vascular Plexus Regression	Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Intracellular Receptor Signaling Pathway
Pathways		Dopamine clearance from the synaptic cleft Na+/Cl- dependent neurotransmitter transporters Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs		Amphetamine Phentermine Benzatropine Venlafaxine Loxapine Methylphenidate Meperidine Imipramine Duloxetine Amoxapine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Aripiprazole Ephedra sinica root MMDA Midomafetamine Fencamfamin 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Vanoxerine Nomifensine Altropane Mianserin Tesofensine Trodusquemine Armodafinil Desvenlafaxine Dexmethylphenidate Dasotraline Solriamfetol
Diseases
GWAS		Pancreatic cancer ( 25086665)	Breast cancer ( 29059683) Cystic fibrosis severity ( 21602797) Estimated glomerular filtration rate ( 31015462) Eye color ( 33692100) Fat distribution (HIV) ( 21897333) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Systolic blood pressure ( 30224653)
Interacting Genes		11 interacting genes: AHRR DRD2 MRPL36 MTNR1A NEDD4 PICK1 RACK1 SNCA SNTA1 STX1A TGFB1I1	3 interacting genes: ADCY2 ARNT SLC6A3
Entrez ID		6531	57491
HPRD ID		00543	07356
Ensembl ID		ENSG00000142319	ENSG00000063438
Uniprot IDs		Q01959	A9YTQ3
PDB IDs			5Y7Y
Enriched GO Terms of Interacting Partners?
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