PYCR3 and LBP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PYCR3	LBP
Description		pyrroline-5-carboxylate reductase 3	lipopolysaccharide binding protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intercellular Bridge Mitotic Spindle	Extracellular Region Extracellular Space Cell Surface Membrane Extracellular Exosome
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding	Lipopolysaccharide Binding Signaling Receptor Binding Protein Binding Lipoteichoic Acid Binding Lipopeptide Binding
	Biological Process	L-proline Biosynthetic Process	Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Macromolecule Localization Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Cytolysis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis
Pathways		Glutamate and glutamine metabolism	Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling
Drugs		Proline
Diseases
GWAS			Basophil percentage of white cells ( 32888494) Blood protein levels ( 29875488) Periodontitis (DPAL) ( 24024966)
Interacting Genes		10 interacting genes: BAG4 CDKN2B FXR1 FXR2 HOXA1 LBP NTAQ1 PRMT6 PSMB1 SDCBP	19 interacting genes: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 CTNNBL1 FTH1 HSPB1 PRDX4 PSMA3 PYCR3 RPS21 SETD1A SMAD3 TRA2A TSC22D4
Entrez ID		65263	3929
HPRD ID		15196	07175
Ensembl ID		ENSG00000104524	ENSG00000129988
Uniprot IDs		A0A0A0MQS1 B4DGI7 Q53H96	P18428 Q8TCF0
PDB IDs
Enriched GO Terms of Interacting Partners?
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