LBP and TRA2A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		LBP	TRA2A
Description		lipopolysaccharide binding protein	transformer 2 alpha homolog
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Membrane Extracellular Exosome	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Intracellular Membrane-bounded Organelle
	Molecular Function	Lipopolysaccharide Binding Signaling Receptor Binding Protein Binding Lipoteichoic Acid Binding Lipopeptide Binding	RNA Binding Protein Binding
	Biological Process	Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Macromolecule Localization Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Cytolysis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis	MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 29875488) Periodontitis (DPAL) ( 24024966)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 CTNNBL1 FTH1 HSPB1 PRDX4 PSMA3 PYCR3 RPS21 SETD1A SMAD3 TRA2A TSC22D4	83 interacting genes: C11orf58 CD86 CDK2AP2 CDK6 CRABP1 DHX15 LBP MAGOHB MIR1-1 MIR1-2 MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR199A1 MIR199A2 MIR19A MIR19B1 MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I MPHOSPH9 NUDT21 NXF1 PPP1CC RNPS1 SELENBP1 SRPK2 SRSF10 TNNT1 U2SURP XPOT YTHDC1 YWHAG
Entrez ID		3929	29896
HPRD ID		07175	04096
Ensembl ID		ENSG00000129988	ENSG00000164548
Uniprot IDs		P18428 Q8TCF0	Q13595 Q549U1
PDB IDs
Enriched GO Terms of Interacting Partners?
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