NADK and CRY2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NADK	CRY2
Description		NAD kinase	cryptochrome circadian regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck
	Molecular Function	NAD+ Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Nuclear Receptor Binding Protein Kinase Binding Phosphatase Binding FAD Binding
	Biological Process	NADP Biosynthetic Process Phosphorylation NAD Metabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus ATP Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Protein Import Into Nucleus Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Lipid Storage Negative Regulation Of Phosphoprotein Phosphatase Activity Response To Insulin Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways		Nicotinate metabolism	Circadian Clock
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971 28892062) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Multiple sclerosis ( 31604244) Pulse pressure ( 28135244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 28135244 30578418)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) Glycemic traits (pleiotropy) ( 31021400) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)
Interacting Genes		10 interacting genes: CRY2 EEF1G FAM124B GLRX3 GRB2 LNX1 NUDT18 SDCBP SRPK2 YWHAQ	54 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 CYSRT1 DELEC1 EZH2 FBXL21P FBXL3 KLHL6 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP19-6 KRTAP4-2 KRTAP5-1 KRTAP5-2 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-8 LMNA MID1 MTUS2 NADK NBPF19 NOTCH2NLA NPAS2 PDE9A PER1 PER2 PER3 PICK1 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGER4 PTGES2 SBK3 SDCBP2 STK11 TIMELESS TNFRSF9 TRAF1 TRAF2 TTC1 VWC2 XRN2 ZBTB42
Entrez ID		65220	1408
HPRD ID		16907	07226
Ensembl ID		ENSG00000008130	ENSG00000121671
Uniprot IDs		A0A024R058 A0A0A0MR98 O95544 Q6PJ22	A0A0D2X7Z3 A2I2P1 Q49AN0
PDB IDs		3PFN
Enriched GO Terms of Interacting Partners?
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