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CRY2 and TRAF1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
CRY2
TRAF1
Description
cryptochrome circadian regulator 2
TNF receptor associated factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Nuclear Speck
Cytoplasm
Cytosol
Cytoplasmic Side Of Plasma Membrane
Plasma Membrane Signaling Receptor Complex
Molecular Function
Transcription Cis-regulatory Region Binding
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Deoxyribodipyrimidine Photo-lyase Activity
DNA (6-4) Photolyase Activity
Protein Binding
Blue Light Photoreceptor Activity
Nuclear Receptor Binding
Protein Kinase Binding
Phosphatase Binding
FAD Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Photoreactive Repair
Protein Import Into Nucleus
Circadian Rhythm
Response To Light Stimulus
Blue Light Signaling Pathway
Response To Activity
Protein-chromophore Linkage
Lipid Storage
Negative Regulation Of Phosphoprotein Phosphatase Activity
Response To Insulin
Circadian Regulation Of Gene Expression
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Transcription, DNA-templated
Regulation Of Sodium-dependent Phosphate Transport
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Negative Regulation Of Glucocorticoid Secretion
Apoptotic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JNK Cascade
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein-containing Complex Assembly
Protein K63-linked Ubiquitination
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Circadian Clock
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Drugs
Diseases
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Axial length (
24144296
)
Fasting blood glucose (
20081858
22581228
)
Fasting blood glucose (BMI interaction) (
22581228
)
Fasting glucose (
33402679
34059833
)
Glycemic traits (pleiotropy) (
31021400
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
30297969
)
Visceral fat (
22589738
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30891314
24782177
23143596
24390342
20453842
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
White blood cell count (
32888494
)
Interacting Genes
54 interacting genes:
ATXN1
BHLHE41
BRCA1
CLOCK
CTBP1
CYSRT1
DELEC1
EZH2
FBXL21P
FBXL3
KLHL6
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP19-6
KRTAP4-2
KRTAP5-1
KRTAP5-2
KRTAP5-4
KRTAP5-7
KRTAP5-9
KRTAP6-3
KRTAP9-8
LMNA
MID1
MTUS2
NADK
NBPF19
NOTCH2NLA
NPAS2
PDE9A
PER1
PER2
PER3
PICK1
PPP2R1B
PPP2R5D
PPP2R5E
PPP5C
PTGER4
PTGES2
SBK3
SDCBP2
STK11
TIMELESS
TNFRSF9
TRAF1
TRAF2
TTC1
VWC2
XRN2
ZBTB42
250 interacting genes:
A1CF
ABHD17A
ACTN3
AKAP17A
AQP1
ARID5A
ARNT2
ARSJ
BARD1
BCAS2
BCL6
BEX2
BEX3
BIRC2
BIRC3
C1orf109
C1orf216
C2CD6
C4orf45
CARHSP1
CASP10
CASP3
CASP6
CASP8
CCDC116
CCDC120
CCDC146
CCDC185
CCDC187
CCDC198
CCHCR1
CD40
CDC20
CDCA3
CDK18
CDKN1A
CDKN2B
CFLAR
CHCHD3
CNTRL
COX5B
CRACR2A
CRY2
CRYGA
CYB5R2
DEPTOR
DGCR6
DMRT3
DOK3
DUSP13
DUSP21
DUSP4
EBF2
EDAR
EHHADH
ENG
ENKD1
EWSR1
FAM161A
FAM161B
FAM86C1P
FBF1
FBXL18
FOSL2
GADD45GIP1
GATA1
GATA2
GATAD2B
GCA
GCM2
GEM
GFI1B
GIT2
GLIS3
GLRX3
GMCL2
GNG5
GOLGA2
GORASP2
GRAP2
HAUS1
HELT
HEY2
HGS
HIVEP3
HMG20B
HNRNPM
HOXA1
HOXB5
HOXC8
HOXD12
IKBKB
JOSD1
KANK2
KIAA1217
KIF1A
KLHL38
KPNA2
KRT3
KRT75
LATS1
LCOR
LIN37
LMNTD2
LNX1
LNX2
LRRN1
LTBR
MACIR
MAP3K14
MAP6
MAPRE2
MATR3
METTL17
MORN3
MOS
MSGN1
MYEF2
MYOZ1
NEBL
NOL4L-DT
NTAQ1
NUFIP2
NUP58
OLIG3
PATZ1
PBX3
PDE4D
PHF21A
PIN1
PITX1
PITX2
PKN1
PLAC8
PLEKHN1
POM121L4P
POP5
PPP1R13B
PPP1R32
PRDM7
PRKAB2
PSMA1
PSMB1
QRICH1
RASAL2
RASSF5
RBCK1
RBM41
RBM45
RCOR3
RIIAD1
RIPK1
RIPK2
RIPOR3
RIPPLY1
RNF31
RTP5
SAMD11
SCAMP1
SCNM1
SDCBP2
SH3GLB2
SHARPIN
SHC3
SHFL
SIK3
SLC25A48
SLC25A6
SNRNP25
SNW1
SOHLH1
SPATA46
SPG21
SPOP
SPTAN1
SRC
SSC5D
STK3
SUMO2
SYCE1
TANK
TBC1D16
TBC1D8
TBX18
TCEA2
TCF7L2
TCL1A
TEAD4
TFAP2D
TFAP4
TFPT
THAP7
TICAM1
TIFA
TLE5
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF9
TRADD
TRAF2
TRAF3IP2
TRAF6
TRAIP
TRIM23
TRIM37
TRIM42
TRPV6
TSHZ2
TSSC4
USP2
USP7
UTP14C
VEZF1
WAC
ZBTB1
ZBTB16
ZC2HC1C
ZFYVE21
ZFYVE26
ZIC1
ZNF124
ZNF20
ZNF23
ZNF250
ZNF417
ZNF440
ZNF490
ZNF502
ZNF512B
ZNF564
ZNF572
ZNF581
ZNF587
ZNF627
ZNF648
ZNF662
ZNF669
ZNF688
ZNF697
ZNF844
Entrez ID
1408
7185
HPRD ID
07226
03418
Ensembl ID
ENSG00000121671
ENSG00000056558
Uniprot IDs
A0A0D2X7Z3
A2I2P1
Q49AN0
Q13077
PDB IDs
3M0D
5E1T
5H10
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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