SLC2A4 and P3H1

Number of citations of the paper that reports this interaction (PubMedID 16396496)
30

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SLC2A4	P3H1
Description		solute carrier family 2 member 4	prolyl 3-hydroxylase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Protein-containing Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity	Molecular_function Iron Ion Binding Protein Binding Collagen Binding Procollagen-proline 3-dioxygenase Activity L-ascorbic Acid Binding
	Biological Process	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol Glucose Import Brown Fat Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier Glucose Transmembrane Transport	Protein Folding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Protein Hydroxylation Peptidyl-proline Hydroxylation Collagen Metabolic Process Regulation Of Protein Secretion Protein Stabilization Bone Development Chaperone-mediated Protein Folding Negative Regulation Of Post-translational Protein Modification
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation	Collagen biosynthesis and modifying enzymes
Drugs			Ascorbic acid Proline
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Liver enzyme levels (alanine transaminase) ( 33972514) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Two-hour glucose ( 34059833)
Interacting Genes		40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N	14 interacting genes: CDC42 JAK1 MIR1-2 MIR107 MIR141 MIR18B MIR19A MIR19B1 MIR9-3 MIR92A1 MIRLET7A2 MIRLET7B MIRLET7I SLC2A4
Entrez ID		6517	64175
HPRD ID		00688	11227
Ensembl ID		ENSG00000181856	ENSG00000117385
Uniprot IDs		P14672	Q32P28
PDB IDs
Enriched GO Terms of Interacting Partners?
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