SLC2A4 and DLD

Number of citations of the paper that reports this interaction (PubMedID 16396496)
30

Data Source:
HPRD (in vivo)

		SLC2A4	DLD
Description		solute carrier family 2 member 4	dihydrolipoamide dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Nucleus Mitochondrion Mitochondrial Matrix Motile Cilium Acrosomal Matrix Oxoglutarate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity	Dihydrolipoyl Dehydrogenase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Lipoamide Binding Flavin Adenine Dinucleotide Binding NAD Binding
	Biological Process	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol Glucose Import Brown Fat Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier Glucose Transmembrane Transport	2-oxoglutarate Metabolic Process Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Gastrulation Aging Lipoate Metabolic Process Regulation Of Membrane Potential Cell Redox Homeostasis Sperm Capacitation Dihydrolipoamide Metabolic Process Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate Histone Succinylation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Glycine degradation Pyruvate metabolism Branched-chain amino acid catabolism Lysine catabolism Citric acid cycle (TCA cycle)
Drugs			NADH Flavin adenine dinucleotide
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Liver enzyme levels (alanine transaminase) ( 33972514) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Two-hour glucose ( 34059833)	Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 23128233 20228799 19122664) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N	5 interacting genes: ITGB1BP1 OGDH OGT PDHX SLC2A4
Entrez ID		6517	1738
HPRD ID		00688	02006
Ensembl ID		ENSG00000181856	ENSG00000091140
Uniprot IDs		P14672	A0A024R713 E9PEX6 P09622
PDB IDs			1ZMC 1ZMD 1ZY8 2F5Z 3RNM 5J5Z 5NHG 6HG8 6I4P 6I4Q 6I4R 6I4S 6I4T 6I4U 6I4Z
Enriched GO Terms of Interacting Partners?
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