WNK1 and YWHAE

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		WNK1	YWHAE
Description		WNK lysine deficient protein kinase 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleus Cytoplasm Cytosol Kinesin Complex Plasma Membrane Focal Adhesion Membrane Melanosome Extracellular Exosome Central Region Of Growth Cone Glutamatergic Synapse
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein Serine Kinase Activity	RNA Binding Calcium Channel Regulator Activity Protein Binding Potassium Channel Regulator Activity Enzyme Binding MHC Class II Protein Complex Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Transmembrane Transporter Binding Cadherin Binding Protein Heterodimerization Activity Phosphoserine Residue Binding Phosphoprotein Binding Scaffold Protein Binding
	Biological Process	Regulation Of Sodium Ion Transport Positive Regulation Of Systemic Arterial Blood Pressure Protein Phosphorylation Ion Transport Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Activation Of Protein Kinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Kinase Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Protein Autophosphorylation Neuron Development Regulation Of Cellular Process Ion Homeostasis T Cell Receptor Signaling Pathway Cellular Response To Calcium Ion Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Cellular Response To Chemokine Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	MAPK Cascade Regulation Of Heart Rate By Hormone Signal Transduction Regulation Of Mitotic Cell Cycle Substantia Nigra Development Protein Localization To Nucleus Cellular Response To Heat Cellular Protein Localization Intracellular Signal Transduction Positive Regulation Of Protein Export From Nucleus Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Pathways		Stimuli-sensing channels	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs
Drugs			Fusicoccin Phenethyl Isothiocyanate
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 29875488) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)	Atrial fibrillation ( 30061737) High light scatter reticulocyte percentage of red cells ( 32888494) Left ventricular mass to end-diastolic volume ratio (MTAG) ( 33495596) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Reaction time ( 29844566) Schizophrenia ( 28991256 30285260)
Interacting Genes		35 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	148 interacting genes: - ABL1 ACD AKAP13 AKAP9 ANKHD1-EIF4EBP3 ANKZF1 ARHGEF2 ARHGEF28 ATP6V0B ATXN1 BAD BCR BEX3 CALM1 CAP2 CASK CASP3 CCDC125 CCR9 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP131 CEP95 CGNL1 CHAF1A CHST11 CYSLTR2 DDX54 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FGF12 FHL1 FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GSTM3 GTF2B HDAC4 HDAC5 HIVEP2 HNRNPC HSF1 HSP90AA1 HSPB1 IGF1R IL7R ING1 IRAG2 IRS1 IRS2 ITPRID2 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KLC4 KRT18 LCP2 MAGEB4 MAP3K1 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MCM10 MDM4 METAP2 MSL2 MST1R MT-CO2 MYH10 NAF1 NCOR2 NDEL1 NIN PAPOLA PARD3B PCM1 PIMREG PNLIP POT1 PRC1 PRDX6 PRKCG RAB11FIP2 RAF1 RAP1GAP2 RASAL3 RASGRF1 RBIS RBM14 REM1 RGS3 RIN1 RPA2 RPGR RXFP3 SAMSN1 SH3BP4 SLC8A1 SLC8A2 SLC8A3 SMAGP SNAPIN SNCA SNF8 SORBS2 SRC SYN2 TAF7 TAFAZZIN TBC1D3F TBP TCEANC TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 UBE3A USP43 VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZC3HC1 ZNF839
Entrez ID		65125	7531
HPRD ID		05570	05457
Ensembl ID		ENSG00000060237	ENSG00000108953
Uniprot IDs		A5D8Z4 F5GWT4 Q9H4A3	P62258 V9HW98
PDB IDs		4PWN 5TF9 5WDY 5WE8 6FBK	2BR9 3UAL 3UBW 6EIH
Enriched GO Terms of Interacting Partners?
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