SKIV2L and CACNB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SKIV2L	CACNB3
Description		Ski2 like RNA helicase	calcium voltage-gated channel auxiliary subunit beta 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Ski Complex	Cytosol Voltage-gated Calcium Channel Complex Membrane Apical Plasma Membrane Synapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding Hydrolase Activity	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Protein Binding High Voltage-gated Calcium Channel Activity Protein Kinase Binding
	Biological Process	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay	Calcium Ion Transport Chemical Synaptic Transmission Neuromuscular Junction Development T Cell Receptor Signaling Pathway Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Cellular Response To Oxygen-glucose Deprivation Regulation Of Membrane Repolarization During Action Potential Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Membrane Hyperpolarization Negative Regulation Of Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease	Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Magnesium sulfate Levomenthol Miconazole Amiodarone Mibefradil Dronedarone Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23577725 20861866) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Platelet count ( 32888494) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908) vWF levels ( 30586737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 PRODH RHOU SNRPB TNRC17 TSSK2 WDR1 XRN1	13 interacting genes: C20orf85 CACNA1B CACNA1C CDK2 CEP76 CIAPIN1 CTBP2 FASLG GEM MEOX1 MTUS2 SKIV2L SYT1
Entrez ID		6499	784
HPRD ID		02724	11879
Ensembl ID		ENSG00000204351	ENSG00000167535
Uniprot IDs		A0A1U9X8J1 Q15477	P54284
PDB IDs
Enriched GO Terms of Interacting Partners?
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