USP46 and CEP135

		USP46	CEP135
Description		ubiquitin specific peptidase 46	centrosomal protein 135
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GO Annotations	Cellular Component	Nucleus Cytosol Glutamatergic Synapse	Centrosome Centriole Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Metal Ion Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Behavioral Fear Response Ubiquitin-dependent Protein Catabolic Process Adult Feeding Behavior Protein Deubiquitination Regulation Of Synaptic Transmission, GABAergic Behavioral Response To Ethanol Righting Reflex Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Centriole Replication Centriole-centriole Cohesion Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Height ( 31562340) Platelet count ( 29403010) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)	Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: CEP135 FXR1 GRIA1 H2AC20 H2BC21 MAPK8IP2 UBA52 UBC WDR20	7 interacting genes: CLOCK DCUN1D4 PIBF1 REST SMAD9 SPINK2 USP46
Entrez ID		64854	9662
HPRD ID		07507	11097
Ensembl ID		ENSG00000109189	ENSG00000174799
Uniprot IDs		P62068	Q66GS9
PDB IDs		5CVM 5CVN 5CVO 5L8H 6JLQ	5FCN 5NG4
Enriched GO Terms of Interacting Partners?
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