CEP135 and CLOCK

		CEP135	CLOCK
Description		centrosomal protein 135	clock circadian regulator
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GO Annotations	Cellular Component	Centrosome Centriole Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytosol Chromatoid Body Intracellular Membrane-bounded Organelle CLOCK-BMAL Transcription Complex
	Molecular Function	Protein Binding Protein C-terminus Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Centriole Replication Centriole-centriole Cohesion Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization	DNA Damage Checkpoint Signaling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Acetylation Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Histone Acetylation Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression HATs acetylate histones Circadian Clock Heme signaling
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Neutrophil percentage of white cells ( 32888494) Personality dimensions ( 18957941) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: CLOCK DCUN1D4 PIBF1 REST SMAD9 SPINK2 USP46	27 interacting genes: ARNTL ARNTL2 BHLHE41 CEP135 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B NPAS2 PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1
Entrez ID		9662	9575
HPRD ID		11097	03508
Ensembl ID		ENSG00000174799	ENSG00000134852
Uniprot IDs		Q66GS9	O15516 Q3ZCT4 Q53EU0
PDB IDs		5FCN 5NG4	4H10 6QPJ
Enriched GO Terms of Interacting Partners?
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