FNDC3B and SPSB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FNDC3B	SPSB2
Description		fibronectin type III domain containing 3B	splA/ryanodine receptor domain and SOCS box containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Binding	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process		Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bell's palsy ( 33602968) Central corneal thickness ( 32528159 31798171 29760442 30894546) Corneal hysteresis ( 30894546) Corneal resistance factor ( 31246245 30894546) Corneal structure ( 23291589) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 33627673) Glycated hemoglobin levels ( 34059833 28898252) Heart rate ( 23583979) Height ( 28552196 25282103 25429064 23563607 31562340 33713608) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Hypertrophic cardiomyopathy ( 33495596 33495597) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 29617998 25173106 31798171 29785010 30054594 28073927 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Keratoconus ( 33649486) Mean corpuscular hemoglobin ( 32888494) Myocardial infarction ( 33532862) Parkinson's disease ( 26227905) PR interval ( 32439900) Pulse pressure ( 30224653) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triptolide cytotoxicity ( 26121980) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Colorectal cancer ( 26965516) Refractive error ( 32231278)
Interacting Genes		52 interacting genes: ABHD11 ABHD8 ADGRF5 BBS2 BICRAL BRWD1 C10orf55 C10orf82 C19orf54 C22orf15 CAMK2D CAPN3 CEMP1 DAPL1 DUSP10 ERCC6 GAS2L3 HAPLN2 KLHDC7B KRTAP11-1 L3MBTL3 MBD3L1 MCCD1 MVP NDUFAB1 PIK3R4 POGZ POU6F2 PRKAA2 REL RUSC1 SPSB2 SRARP STPG4 SUOX TEKT5 TEPSIN TESMIN TEX43 TEX48 TIAM1 TOX4 TRAF2 TRIM35 TRIM42 TRIP13 TTN UBAP2 USP54 VAC14 YPEL3 ZMYND19	12 interacting genes: APP DDX4 FNDC3B GALNT15 NOS2 NRF1 PAWR PRMT1 RECK SMARCD1 TRIM55 TRIM63
Entrez ID		64778	84727
HPRD ID		10943	13610
Ensembl ID		ENSG00000075420	ENSG00000111671
Uniprot IDs		Q53EP0	Q99619
PDB IDs			3EMW 5XN3 6DN5 6DN6 6JKJ 6JWM 6JWN 6KEY
Enriched GO Terms of Interacting Partners?
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