SH3GL2 and TIAM2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		SH3GL2	TIAM2
Description		SH3 domain containing GRB2 like 2, endophilin A1	TIAM Rac1 associated GEF 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Basal Dendrite Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Cytosol Membrane Lamellipodium Filopodium Growth Cone Perikaryon Synapse Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Protein Kinase Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Neuron Projection Development Synaptic Vesicle Endocytosis Lipid Tube Assembly Dendrite Extension Membrane Tubulation Membrane Bending Vesicle Scission Positive Regulation Of Membrane Tubulation Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Clathrin-dependent Endocytosis	Small GTPase Mediated Signal Transduction Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	NRAGE signals death through JNK PPARA activates gene expression G alpha (12/13) signalling events RAC1 GTPase cycle
Drugs
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) HDL cholesterol levels in HIV infection ( 33109212) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Parkinson's disease ( 22451204 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 31361310) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Heel bone mineral density ( 30598549) Lipoprotein (a) levels ( 26377243) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		53 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 FXR1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SHANK3 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	9 interacting genes: ANXA7 DISC1 DNM2 H2AX PARD3 SH3GL2 TK1 TNIK UFD1
Entrez ID		6456	26230
HPRD ID		05125	05273
Ensembl ID		ENSG00000107295	ENSG00000146426
Uniprot IDs		Q7Z376 Q99962	B3KW11 Q8IVF5
PDB IDs		1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?
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